Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways
文献类型：期刊论文
| 作者 | Liang, Xing2; Liu, Anan2; Chen, Danlei2; Tang, Liang2; Chen, Jun2; Shao, Chenghao1,2; Qi, Meiyan3; Zhan, Lixing3; Wu, Rui4; Hu, Xiangui1 |
| 刊名 | INTERNATIONAL JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 53期号:6页码:2671-2682 |
| 关键词 | pancreatic neoplasm long non-coding RNA cancer upregulated drug resistance epithelial-mesenchymal transition protein kinase B extracellular-signal-regulated kinase |
| ISSN号 | 1019-6439 |
| DOI | 10.3892/ijo.2018.4574 |
| 文献子类 | Article |
| 英文摘要 | Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a marked potential for invasion and metastasis. Emerging evidence has suggested that dysregulation of long non-coding RNAs (lncRNAs) is associated with the development of multiple types of cancer. However, the function of lncRNAs in PDAC is poorly known. In the present study, a microarray assay was used to screen for differently expressed lncRNAs in PDAC and it was identified that cancer upregulated drug resistance (CUDR) was upregulated in PDAC. CUDR increased PDAC cell proliferation, migration and invasion, inhibited apoptosis, and promoted drug resistance; it also regulated the PDAC cell epithelial-mesenchymal transition. The CUDR-induced PDAC malignant phenotypes is via the protein kinase B and extracellular-signal-regulated kinase signaling pathways. Downregulation of CUDR may be a novel therapeutic strategy to prevent PDAC development and drug resistance in the future. |
| 学科主题 | Oncology |
| WOS关键词 | TO-MESENCHYMAL TRANSITION ; CANCER-CELLS ; DRUG-RESISTANCE ; GASTRIC-CANCER ; E-CADHERIN ; EXPRESSION ; METASTASIS ; GROWTH ; UCA1 ; INVASION |
| 语种 | 英语 |
| WOS记录号 | WOS:000448952100029 |
| 出版者 | SPANDIDOS PUBL LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/865]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Second Mil Med Univ, Changhai Hosp, Dept Pancreat Surg, Shanghai 200433, Peoples R China; 2.Second Mil Med Univ, Changzheng Hosp, Dept Pancreat Biliary Surg, Fengyang Rd 415, Shanghai 200003, Peoples R China; 3.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Inst Nutr Sci,Key Lab Food Safety Res, Taiyuan Rd 294, Shanghai 200031, Peoples R China; 4.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Biliary Surg 1, Shanghai 200433, Peoples R China; 5.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Gen Surg Dept, Hangzhou 310016, Zhejiang, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liang, Xing,Liu, Anan,Chen, Danlei,et al. Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2018,53(6):2671-2682. |
| APA | Liang, Xing.,Liu, Anan.,Chen, Danlei.,Tang, Liang.,Chen, Jun.,...&,.(2018).Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways.INTERNATIONAL JOURNAL OF ONCOLOGY,53(6),2671-2682. |
| MLA | Liang, Xing,et al."Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways".INTERNATIONAL JOURNAL OF ONCOLOGY 53.6(2018):2671-2682. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。