Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies
文献类型：期刊论文
| 作者 | Chen, Jie-Hua2; Bu, Cuihong2; Zhang, Xuguang2; Lin, Xu1; , |
| 刊名 | NUTRITION & METABOLISM
 |
| 出版日期 | 2018 |
| 卷号 | 15期号:-页码:72 |
| 关键词 | Advanced glycation end products (AGEs) Mobility AGEs inhibitors Dietary intervention strategies |
| ISSN号 | 1743-7075 |
| DOI | 10.1186/s12986-018-0306-7 |
| 文献子类 | Review |
| 英文摘要 | Advanced glycation end products (AGEs), a group of compounds that are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of proteins, lipids or nucleic acids, can be obtained exogenously from diet or formed endogenously within the body. AGEs accumulate intracellularly and extracellularly in all tissues and body fluids and can cross-link with other proteins and thus affect their normal functions. Furthermore, AGEs can interact with specific cell surface receptors and hence alter cell intracellular signaling, gene expression, the production of reactive oxygen species and the activation of several inflammatory pathways. High levels of AGEs in diet as well as in tissues and the circulation are pathogenic to a wide range of diseases. With respect to mobility, AGEs accumulate in bones, joints and skeletal muscles, playing important roles in the development of osteoporosis, osteoarthritis, and sarcopenia with aging. This report covered the related pathological mechanisms and the potential pharmaceutical and dietary intervention strategies in reducing systemic AGEs. More prospective studies are needed to determine whether elevated serum AGEs and/or skin autofluorescence predict a decline in measures of mobility. In addition, human intervention studies are required to investigate the beneficial effects of exogenous AGEs inhibitors on mobility outcomes. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | MAILLARD REACTION-PRODUCTS ; RENAL-FAILURE PATIENTS ; EXPERIMENTAL DIABETIC-RETINOPATHY ; N-EPSILON-CARBOXYMETHYLLYSINE ; LEUKEMIA INHIBITORY FACTOR ; LOW-DENSITY-LIPOPROTEIN ; PROTEIN CROSS-LINKING ; OXIDATIVE STRESS ; SKIN AUTOFLUORESCENCE ; IN-VITRO |
| 语种 | 英语 |
| WOS记录号 | WOS:000447241300001 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/869]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China, 2.By Hlth Co Ltd, Sci & Technol Ctr, 3 Kehui 3rd St, 99 Kexue Ave Cent, Guangzhou 510000, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Jie-Hua,Bu, Cuihong,Zhang, Xuguang,et al. Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies[J]. NUTRITION & METABOLISM,2018,15(-):72. |
| APA | Chen, Jie-Hua,Bu, Cuihong,Zhang, Xuguang,Lin, Xu,&,.(2018).Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies.NUTRITION & METABOLISM,15(-),72. |
| MLA | Chen, Jie-Hua,et al."Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies".NUTRITION & METABOLISM 15.-(2018):72. |
入库方式： OAI收割
来源：上海营养与健康研究所
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