Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores beta cells and reconstructs gut microbiota in mice
文献类型：期刊论文
| 作者 | Wei, Siying; Han, Ruomei; Zhao, Jingyu; Wang, Shuo; Huang, Meiqin; Wang, Yining; Chen, Yan; , |
| 刊名 | NUTRITION & METABOLISM
 |
| 出版日期 | 2018 |
| 卷号 | 15期号:-页码:80 |
| 关键词 | Diabetes Intermittent fasting Fasting-mimicking diet Beta cells Fatty liver Gut microbiota |
| ISSN号 | 1743-7075 |
| DOI | 10.1186/s12986-018-0318-3 |
| 文献子类 | Article |
| 英文摘要 | Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorate metabolic disorders. To investigate the effect of a new type of low-protein low-carbohydrate FMD on diabetes, we tested an FMD in db/db mice, a genetic model of type 2 diabetes. The diet was administered every other week for a total of 8 weeks. The intermittent FMD normalized blood glucose levels in db/db mice, with significant improvements in insulin sensitivity and beta cell function. The FMD also reduced hepatic steatosis in the mice. Deterioration of pancreatic islets and the loss of beta cells in the diabetic mice were prevented by the FMD. The expression of beta cell progenitor marker Ngn3 was increased by the FMD. In addition, the FMD led to the reconstruction of gut microbiota. Intermittent application of the FMD increased the genera of Parabacteroides and Blautia while reducing Prevotellaceae, Alistipes and Ruminococcaceae. The changes in these bacteria were also correlated with the fasting blood glucose levels of the mice. Furthermore, intermittent FMD was able to reduce fasting blood glucose level and increase beta cells in STZ-induced type 1 diabetic mouse model. In conclusion, our study provides evidence that the intermittent application of an FMD is able to effectively intervene in the progression of diabetes in mice. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | INSULIN-RESISTANCE ; ENERGY-INTAKE ; WEIGHT-LOSS ; RESTRICTION ; REGENERATION ; METAGENOME ; DEFICIENT ; HEALTH ; AGE |
| 语种 | 英语 |
| WOS记录号 | WOS:000451212300001 |
| 出版者 | BMC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/870]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wei, Siying,Han, Ruomei,Zhao, Jingyu,et al. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores beta cells and reconstructs gut microbiota in mice[J]. NUTRITION & METABOLISM,2018,15(-):80. |
| APA | Wei, Siying.,Han, Ruomei.,Zhao, Jingyu.,Wang, Shuo.,Huang, Meiqin.,...&,.(2018).Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores beta cells and reconstructs gut microbiota in mice.NUTRITION & METABOLISM,15(-),80. |
| MLA | Wei, Siying,et al."Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores beta cells and reconstructs gut microbiota in mice".NUTRITION & METABOLISM 15.-(2018):80. |
入库方式： OAI收割
来源：上海营养与健康研究所
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