ALUternative Regulation for Gene Expression
文献类型：期刊论文
| 作者 | Chen, Ling-Ling1,3; Yang, Li2; Yang, Li3; , |
| 刊名 | TRENDS IN CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:7页码:480-490 |
| 关键词 | Epidemics Pandemics Propagation dynamics of infectious diseases Quasispecies |
| ISSN号 | 0962-8924 |
| DOI | 10.1016/j.tcb.2017.01.002 |
| 文献子类 | Review |
| 英文摘要 | Alu elements belong to the primate-specific SINE family of retrotransposons and constitute almost 11% of the human genome. Alus are transcribed by RNA polymerase (Pol) III and are inserted back into the genome with the help of autonomous LINE retroelements. Since Alu elements are preferentially located near to or within gene-rich regions, they can affect gene expression by distinct mechanisms of action at both DNA and RNA levels. In this review we focus on recent advances of how Alu elements are pervasively involved in gene regulation. We discuss the impacts of Alu DNA sequences that are in close proximity to genes, Pol-III-transcribed free Alu RNAs, and Pol-II-transcribed Alu RNAs that are embedded within coding or noncoding RNA transcripts. The recent elucidation of Alu functions reveals previously underestimated roles of these selfish or junk DNA sequences in the human genome. |
| 学科主题 | Cell Biology |
| WOS关键词 | MESSENGER-RNA DECAY ; ALU ELEMENTS ; NUCLEAR RETENTION ; EXON CIRCULARIZATION ; HUMAN MICRORNAS ; EDITING SITES ; HUMAN GENOME ; TRANSPOSABLE ELEMENTS ; HUMAN TRANSCRIPTOME ; CIRCRNA BIOGENESIS |
| 语种 | 英语 |
| WOS记录号 | WOS:000403336600003 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/873]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Key Lab Mol Androl,Shanghai Inst Biochem, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Ling-Ling,Yang, Li,Yang, Li,et al. ALUternative Regulation for Gene Expression[J]. TRENDS IN CELL BIOLOGY,2017,27(7):480-490. |
| APA | Chen, Ling-Ling,Yang, Li,Yang, Li,&,.(2017).ALUternative Regulation for Gene Expression.TRENDS IN CELL BIOLOGY,27(7),480-490. |
| MLA | Chen, Ling-Ling,et al."ALUternative Regulation for Gene Expression".TRENDS IN CELL BIOLOGY 27.7(2017):480-490. |
入库方式： OAI收割
来源：上海营养与健康研究所
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