Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction
文献类型：期刊论文
| 作者 | Qiao, Lu6; Hu, Sile6; Zhou, Hang6; Peng, Shouneng6; Lu, Yan6; Lou, Haiyi6; Lu, Dongsheng6; Wu, Sijie6; Guo, Jing6; Jin, Li6,7,8,9 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2018 |
| 卷号 | 45期号:8页码:419-432 |
| 关键词 | Genome-wide association study Dense 3D facial image Ancestry-divergent phenotypes Face prediction Forensic scenario |
| ISSN号 | 1673-8527 |
| DOI | 10.1016/j.jgg.2018.07.009 |
| 文献子类 | Article |
| 英文摘要 | It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies (GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. Copyright (C) 2018, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | HUMAN HEIGHT ; COMMON SNPS ; ASSOCIATION ; POPULATION ; TRAITS ; DISCOVERY ; ADMIXTURE ; UYGHURS ; EDAR |
| 语种 | 英语 |
| WOS记录号 | WOS:000449714900001 |
| 出版者 | SCIENCE PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/875]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.First Peoples Hosp Chenzhou, Dept Neurol, Chenzhou 423000, Hunan, Peoples R China; 2.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China; 3.Xinjiang Med Univ, Dept Biochem & Mol Biol, Preclin Med Coll, Urumqi 830011, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China, 5.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China; 6.Univ Chinese Acad Sci, CAS, CAS MPG Partner Inst Computat Biol PICB, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 7.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China; 8.Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China; 9.Fudan Taizhou Inst Hlth Sci, Taizhou 225300, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Qiao, Lu,Hu, Sile,Zhou, Hang,et al. Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction[J]. JOURNAL OF GENETICS AND GENOMICS,2018,45(8):419-432. |
| APA | Qiao, Lu.,Hu, Sile.,Zhou, Hang.,Peng, Shouneng.,Lu, Yan.,...&,.(2018).Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction.JOURNAL OF GENETICS AND GENOMICS,45(8),419-432. |
| MLA | Qiao, Lu,et al."Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction".JOURNAL OF GENETICS AND GENOMICS 45.8(2018):419-432. |
入库方式： OAI收割
来源：上海营养与健康研究所
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