Interethnic analyses of blood pressure loci in populations of East Asian and European descent
文献类型：期刊论文
| 作者 | Takeuchi, Fumihiko73,74; Kato, Norihiro73,74; Isono, Masato73; Akiyama, Masato72; Matoba, Nana72; Takahashi, Atsushi72; Kamatani, Yoichiro72; Katsuya, Tomohiro70,71; Rakugi, Hiromi70; Nakatochi, Masahiro69 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:5052 |
| 关键词 | ovarian cancer stromal cells tumor microenvironment therapeutic resistance ectopic metastasis combinational treatment patient stratification |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-07345-0 |
| 文献子类 | Article |
| 英文摘要 | Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP ( max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; BODY-MASS INDEX ; LINKAGE DISEQUILIBRIUM ; CARDIOVASCULAR-DISEASE ; FUNCTIONAL ANNOTATION ; RARE VARIANTS ; COMMON ; METAANALYSIS ; HERITABILITY ; ARCHITECTURE |
| 语种 | 英语 |
| WOS记录号 | WOS:000451433800022 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/877]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tulane Univ, Sch Med, Dept Med, New Orleans, LA 70112 USA; 2.Jichi Med Univ, Sch Med, Dept Environm & Prevent Med, Shimotsuke 3290498, Japan; 3.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 168751, Singapore; 4.RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan, 5.Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto 6068501, Japan; 6.Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi 4648650, Japan; 7.Shimane Univ, Fac Med, Dept Funct Pathol, Izumo, Shimane 6930021, Japan; 8.Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 119077, Singapore; 9.Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore 119228, Singapore; 10.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore 119228, Singapore; |
| 推荐引用方式 GB/T 7714 | Takeuchi, Fumihiko,Kato, Norihiro,Isono, Masato,et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent[J]. NATURE COMMUNICATIONS,2018,9(-):5052. |
| APA | Takeuchi, Fumihiko.,Kato, Norihiro.,Isono, Masato.,Akiyama, Masato.,Matoba, Nana.,...&,.(2018).Interethnic analyses of blood pressure loci in populations of East Asian and European descent.NATURE COMMUNICATIONS,9(-),5052. |
| MLA | Takeuchi, Fumihiko,et al."Interethnic analyses of blood pressure loci in populations of East Asian and European descent".NATURE COMMUNICATIONS 9.-(2018):5052. |
入库方式： OAI收割
来源：上海营养与健康研究所
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