Aldehyde Dehydrogenase-2 (ALDH2) Opposes Hepatocellular Carcinoma Progression by Regulating AMP-Activated Protein Kinase Signaling in Mice
文献类型：期刊论文
| 作者 | Hou, Guojun6,7; Chen, Lei7; Li, Liang2,7; Yan, He-Xin2,7; Zhang, Hui-Lu7; Tang, Jing7; Yang, Ying Cheng7; Lin, Ximeng7; Chen, Xin7; Luo, Gui Juan7 |
| 刊名 | HEPATOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 65期号:5页码:1628-1644 |
| ISSN号 | 0270-9139 |
| DOI | 10.1002/hep.29006 |
| 文献子类 | Article |
| 英文摘要 | Potential biomarkers that can be used to determine prognosis and perform targeted therapies are urgently needed to treat patients with hepatocellular carcinoma (HCC). To meet this need, we performed a screen to identify functional genes associated with hepatocellular carcinogenesis and its progression at the transcriptome and proteome levels. We identified aldehyde dedydrogenase-2 (ALDH2) as a gene of interest for further study. ALDH2 levels were significantly lower at the mRNA and protein level in tumor tissues than in normal tissues, and they were even lower in tissues that exhibited increased migratory capacity. A study of clinical associations showed that ALDH2 is correlated with survival and multiple migration-associated clinicopathological traits, including the presence of metastasis and portal vein tumor thrombus. The result of overexpressing or knocking down ALDH2 showed that this gene inhibited migration and invasion both in vivo and in vitro. We also found that ALDH2 altered the redox status of cells by regulating acetaldehyde levels and that it further activated the AMP-activated protein kinase (AMPK) signaling pathway. Conclusion: Decreased levels of ALDH2 may indicate a poor prognosis in HCC patients, while forcing the expression of ALDH2 in HCC cells inhibited their aggressive behavior in vitro and in mice largely by modulating the activity of the ALDH2-acetaldehyde-redox-AMPK axis. Therefore, identifying ALDH2 expression levels in HCC might be a useful strategy for classifying HCC patients and for developing potential therapeutic strategies that specifically target metastatic HCC. |
| 学科主题 | Gastroenterology & Hepatology |
| WOS关键词 | CANCER STATISTICS ; OXIDATIVE STRESS ; METABOLISM ; METABOLOMICS ; METASTASIS ; RECURRENCE ; MECHANISM ; PROMOTES ; GROWTH ; CELL |
| 语种 | 英语 |
| WOS记录号 | WOS:000399459800016 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/880]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Canc Inst, State Key Lab Oncogenes & Related Genes, RenJi Hosp, Shanghai, Peoples R China, 2.Natl Ctr Liver Canc, Shanghai, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China; 4.Fudan Univ, Inst Biomed Sci, Dongan Rd 150, Shanghai 200032, Peoples R China; 5.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China; 6.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, 225 Changhai Rd, Shanghai 200438, Peoples R China; 7.Second Mil Med Univ, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Hosp, Shanghai, Peoples R China; 8.WuXi AppTec Co Ltd, Oncol Business Unit, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hou, Guojun,Chen, Lei,Li, Liang,et al. Aldehyde Dehydrogenase-2 (ALDH2) Opposes Hepatocellular Carcinoma Progression by Regulating AMP-Activated Protein Kinase Signaling in Mice[J]. HEPATOLOGY,2017,65(5):1628-1644. |
| APA | Hou, Guojun.,Chen, Lei.,Li, Liang.,Yan, He-Xin.,Zhang, Hui-Lu.,...&,.(2017).Aldehyde Dehydrogenase-2 (ALDH2) Opposes Hepatocellular Carcinoma Progression by Regulating AMP-Activated Protein Kinase Signaling in Mice.HEPATOLOGY,65(5),1628-1644. |
| MLA | Hou, Guojun,et al."Aldehyde Dehydrogenase-2 (ALDH2) Opposes Hepatocellular Carcinoma Progression by Regulating AMP-Activated Protein Kinase Signaling in Mice".HEPATOLOGY 65.5(2017):1628-1644. |
入库方式： OAI收割
来源：上海营养与健康研究所
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