Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity
文献类型：期刊论文
| 作者 | Zhang, Yongxian; Gu, Jin; Wang, Lin; Zhao, Zilong; Pan, Yi; Chen, Yan; , |
| 刊名 | MOLECULAR AND CELLULAR ENDOCRINOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 439期号:C页码:133-140 |
| 关键词 | Glycogen Obesity Insulin resistance Hepatic steatosis Adipocytes |
| ISSN号 | 0303-7207 |
| DOI | 10.1016/j.mce.2016.10.036 |
| 文献子类 | Article |
| 英文摘要 | Glycogen and triglyceride are two major forms of energy storage in the body and provide the fuel during different phases of food deprivation. However, how glycogen metabolism is linked to fat deposition in adipose tissue has not been clearly characterized. We generated a mouse model with whole-body deletion of PPP1R3G, a glycogen-targeting subunit of protein phosphatase-1 required for glycogen synthesis. Upon feeding with high-fat diet, the body weight and fat composition are significantly reduced in the PPP1R3G(-/-) mice compared to the wild type controls. The metabolic rate of the mice as measured by O-2 consumption and CO2 production is accelerated by PPPIR3G deletion. The high-fat diet-induced liver steatosis is also slightly relieved by PPP1R3G deletion. The glycogen level in adipose tissue is reduced by PPP1R3G deletion. In 3T3L1 cells, overexpression of PPPIR3G leads to increases of both glycogen and triglyceride levels. In conclusion, our study indicates that glycogen is actively involved in fat accumulation in adipose tissue and obesity development upon high-fat diet. Our study also suggests that PPP1R3G is an important player that links glycogen metabolism to lipid metabolism in vivo. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Cell Biology ; Endocrinology & Metabolism |
| WOS关键词 | INDUCED HEPATIC STEATOSIS ; 1 REGULATORY SUBUNIT ; PROTEIN PHOSPHATASE-1 ; INSULIN-RESISTANCE ; TARGETING SUBUNIT ; ADIPOSE-TISSUE ; GLUCOSE-HOMEOSTASIS ; IN-VIVO ; METABOLISM ; SYNTHASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000391647800015 |
| 出版者 | ELSEVIER IRELAND LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/884]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, CAS Key Lab Nutr & Metab, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Zhang, Yongxian,Gu, Jin,Wang, Lin,et al. Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2017,439(C):133-140. |
| APA | Zhang, Yongxian.,Gu, Jin.,Wang, Lin.,Zhao, Zilong.,Pan, Yi.,...&,.(2017).Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity.MOLECULAR AND CELLULAR ENDOCRINOLOGY,439(C),133-140. |
| MLA | Zhang, Yongxian,et al."Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity".MOLECULAR AND CELLULAR ENDOCRINOLOGY 439.C(2017):133-140. |
入库方式： OAI收割
来源：上海营养与健康研究所
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