Aging-associated oxidative stress inhibits liver progenitor cell activation in mice
文献类型：期刊论文
| 作者 | Cheng, Yiji1,2; Wang, Xue1,2; Luo, Qingquan1,2; Zhou, Qianjun1,2; Zhang, Yanyun1,2,4,5; Wang, Bei4,5; Zhou, Hong4,5; Dang, Shipeng4,5; Shi, Yufang4,5; Jin, Min4,5 |
| 刊名 | AGING-US
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:5页码:1359-1374 |
| 关键词 | aging stem cells liver regeneration neutrophil reactive oxygen species |
| ISSN号 | 1945-4589 |
| DOI | 10.18632/aging.101232 |
| 文献子类 | Article |
| 英文摘要 | Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, leading to the impaired liver regeneration. Surprisingly, isolated LPCs from young and old mice did not exhibit significant difference in their clonogenic and proliferative capacity. Later, we uncovered that the decreased activation and proliferation of LPCs were due to excessive reactive oxygen species produced by neutrophils infiltrated into niche, which was resulted from chemokine production from activated hepatic stellate cells during aging. This study demonstrates aging-associated changes in LPC activation and reveals critical roles for the stem cell niche, including neutrophils and hepatic stellate cells, in the negative regulation of LPCs during aging. |
| 学科主题 | Cell Biology ; Geriatrics & Gerontology |
| WOS关键词 | ETHIONINE-SUPPLEMENTED DIET ; HEPATIC OVAL CELLS ; STEM-CELLS ; CHOLINE-DEFICIENT ; DONOR AGE ; RAT ; TRANSPLANTATION ; MYELOPEROXIDASE ; REGENERATION ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000404467700005 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/885]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Chest Hosp, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai, Peoples R China; 3.Anhui Med Univ, Affiliated Hosp 1, Clin Lab, Hefei, Peoples R China, 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cheng, Yiji,Wang, Xue,Luo, Qingquan,et al. Aging-associated oxidative stress inhibits liver progenitor cell activation in mice[J]. AGING-US,2017,9(5):1359-1374. |
| APA | Cheng, Yiji.,Wang, Xue.,Luo, Qingquan.,Zhou, Qianjun.,Zhang, Yanyun.,...&,.(2017).Aging-associated oxidative stress inhibits liver progenitor cell activation in mice.AGING-US,9(5),1359-1374. |
| MLA | Cheng, Yiji,et al."Aging-associated oxidative stress inhibits liver progenitor cell activation in mice".AGING-US 9.5(2017):1359-1374. |
入库方式： OAI收割
来源：上海营养与健康研究所
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