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Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia

文献类型：期刊论文

作者Jia, Gaozhen2; Dong, Zhenyang2; Wang, Haifeng2; Gao, Xu2; Xu, Chuanliang2; Sun, Yinghao2; Yang, Chenghua3; Sun, Chenxia1; Wen, Fuping1; Yang, Chenghua1
刊名ONCOTARGET
出版日期2017
卷号8期号:44页码:76987-76999
关键词prostate cancer PSA glycosylation benign prostate hyperplasia EPS-urine
ISSN号1949-2553
DOI10.18632/oncotarget.20299
文献子类Article
英文摘要The prostate specific antigen (PSA) test is widely used for early diagnosis of prostate cancer (PCa). However, its limited sensitivity has led to over-diagnosis and over-treatment of PCa. Glycosylation alteration is a common phenomenon in cancer development. Different PSA glycan subforms have been proposed as diagnostic markers to better differentiate PCa from benign prostate hyperplasia (BPH). In this study, we purified PSA from expressed prostate secretions (EPS)-urine samples from 32 BPH and 30 PCa patients and provided detailed PSA glycan profiles in Chinese population. We found that most of the PSA glycans from EPS-urine were complex type biantennary glycans. We observed two major patterns in PSA glycan profiles. Overall there was no distinct separation of PSA glycan profiles between BPH and PCa patients. However, we detected a significant increase of glycan FA2 and FM5A2G2S1 in PCa when compared with BPH patients. Furthermore, we observed that the composition of FA2 glycan increased significantly in advanced PCa with Gleason score >= 8, which potentially could be translated to clinic as a marker for aggressive PCa.
学科主题Oncology ; Cell Biology
WOS关键词SEMINAL PLASMA ; CARBOHYDRATE STRUCTURE ; ALTERED GLYCOSYLATION ; PROTEIN GLYCOSYLATION ; GENE FUSIONS ; ANTIGEN ; SERUM ; GLYCANS ; MASS ; BIOMARKERS
语种英语
WOS记录号WOS:000412066700096
出版者IMPACT JOURNALS LLC
版本出版稿
源URL[http://202.127.25.144/handle/331004/886]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China;
2.Second Mil Med Univ, Changhai Hosp, Dept Urol, Shanghai 2000433, Peoples R China;
3.Second Mil Med Univ, Changhai Hosp, Joint Ctr Translat Res Chron Dis, Shanghai 2000433, Peoples R China;
4.State Key Lab Antibody Med & Targeted Therapy, Shanghai 201203, Peoples R China,
推荐引用方式
GB/T 7714		 Jia, Gaozhen,Dong, Zhenyang,Wang, Haifeng,et al. Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia[J]. ONCOTARGET,2017,8(44):76987-76999.
APA Jia, Gaozhen.,Dong, Zhenyang.,Wang, Haifeng.,Gao, Xu.,Xu, Chuanliang.,...&,.(2017).Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia.ONCOTARGET,8(44),76987-76999.
MLA Jia, Gaozhen,et al."Alterations in expressed prostate secretion-urine PSA N-glycosylation discriminate prostate cancer from benign prostate hyperplasia".ONCOTARGET 8.44(2017):76987-76999.

入库方式： OAI收割

来源：上海营养与健康研究所

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