Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study
文献类型：期刊论文
| 作者 | Jiang, Cheng-Lan1,2; He, Shui-Wang2; Zhang, Yun-Dong2; Duan, He-Xian2; Cao, Yi2; Zhang, Yun-Dong3; Huang, Tao4; Huang, Yun-Chao5; Li, Gao-Feng6; Wang, Ping7 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:1页码:1369-1391 |
| 关键词 | air pollution-related lung cancer DNA methylation benzo(a) pyrene carcinogenesis vitamin |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.13622 |
| 文献子类 | Article |
| 英文摘要 | The lung cancer incidence in the Xuanwei and neighboring region, Yunnan, China, is among the highest in China and is attributed to severe air pollution with high benzo(a) pyrene levels. We systematically and comparatively analyzed DNA methylation alterations at genome and gene levels in Xuanwei lung cancer tissues and cell lines, as well as benzo(a) pyrene-treated cells and mouse samples. We obtained a comprehensive dataset of genome-wide cytosine-phosphate-guanine island methylation in air pollution-related lung cancer samples. Benzo(a) pyrene exposure induced multiple alterations in DNA methylation and in mRNA expressions of DNA methyltransferases and ten-11 translocation proteins; these alterations partially occurred in Xuanwei lung cancer. Furthermore, benzo(a) pyrene-induced DKK2 and EN1 promoter hypermethylation and LPAR2 promoter hypomethylation led to downregulation and up-regulation of the genes, respectively; the down-regulation of DKK2 and EN1 promoted the cellular proliferation. Thus, DNA methylation alterations induced by benzo(a) pyrene contribute partially to abnormal DNA methylation in air pollution-related lung cancer, and these DNA methylation alterations may affect the development and progression of lung cancer. Additionally, vitamin C and B6 can reduce benzo(a) pyrene-induced DNA methylation alterations and may be used as chemopreventive agents for air pollution-related lung cancer. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | POLYCYCLIC AROMATIC-HYDROCARBONS ; GENE-PROMOTER HYPERMETHYLATION ; VITAMIN-C ; FOLLOW-UP ; CELLS ; GENOME ; RISK ; EPIGENETICS ; ASSOCIATION ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000391503300107 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/887]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650223, Peoples R China; 2.Chinese Acad Sci, Kunming Inst Zool, Lab Mol & Expt Pathol, Kunming 650223, Peoples R China; 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 5.Kunming Med Univ, Affiliated Hosp 3, Yunnan Tumor Hosp, Dept Thorac & Cardiovasc Surg, Kunming 650106, Peoples R China; 6.Kunming Med Univ, Affiliated Hosp 3, Yunnan Tumor Hosp, Dept Thorac Surg, Kunming 650106, Peoples R China; 7.First Peoples Hosp Yunnan Province, Dept Thorac Surg, Kunming 650032, Peoples R China; 8.Kunming Med Univ, Affiliated Hosp 1, Clin Med Res Ctr, Kunming 650332, Peoples R China; 9.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Jiang, Cheng-Lan,He, Shui-Wang,Zhang, Yun-Dong,et al. Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study[J]. ONCOTARGET,2017,8(1):1369-1391. |
| APA | Jiang, Cheng-Lan.,He, Shui-Wang.,Zhang, Yun-Dong.,Duan, He-Xian.,Cao, Yi.,...&,.(2017).Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study.ONCOTARGET,8(1),1369-1391. |
| MLA | Jiang, Cheng-Lan,et al."Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study".ONCOTARGET 8.1(2017):1369-1391. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。