An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity
文献类型：期刊论文
| 作者 | Xiao, Yuzhong; Deng, Yalan; Yuan, Feixiang; Xia, Tingting; Liu, Hao; Li, Zhigang; Chen, Shanghai; Liu, Zhixue; Ying, Hao; Liu, Yi |
| 刊名 | AUTOPHAGY
 |
| 出版日期 | 2017 |
| 卷号 | 13期号:6页码:1088-1089 |
| 关键词 | ATF4 ATG5 autophagy POMC neurons obesity |
| ISSN号 | 1554-8627 |
| DOI | 10.1080/15548627.2017.1307488 |
| 文献子类 | Article |
| 英文摘要 | ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-a) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and have higher energy expenditure. Furthermore, these mice are resistant to high-fat diet (HFD)-induced obesity and obesity-related metabolic disorders. Mechanistically, we found the expression of ATG5 (autophagy-related 5) is upregulated in POMC neurons of PAKO mice, and ATF4 regulates ATG5 expression by binding directly to its promoter. Mice with Atf4 and Atg5 double knockout in POMC neurons have reduced energy expenditure and gain more fat mass compared with PAKO mice under a HFD. Finally, the effect of Atf4 knockout in POMC neurons is possibly mediated by enhanced ATG5-dependent macroautophagy/autophagy and alpha-melanocyte-stimulating hormone (alpha-MSH) production in the hypothalamus. Together, this work not only identifies a beneficial role for ATF4 in hypothalamic POMC neurons in the regulation of obesity, but also provides a new potential therapeutic target for obesity and obesity-related metabolic diseases. |
| 学科主题 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000404150600014 |
| 出版者 | TAYLOR & FRANCIS INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/889]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xiao, Yuzhong,Deng, Yalan,Yuan, Feixiang,et al. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity[J]. AUTOPHAGY,2017,13(6):1088-1089. |
| APA | Xiao, Yuzhong.,Deng, Yalan.,Yuan, Feixiang.,Xia, Tingting.,Liu, Hao.,...&,.(2017).An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity.AUTOPHAGY,13(6),1088-1089. |
| MLA | Xiao, Yuzhong,et al."An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity".AUTOPHAGY 13.6(2017):1088-1089. |
入库方式： OAI收割
来源：上海营养与健康研究所
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