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Assessing the activity of nonsense-mediated mRNA decay in lung cancer

文献类型：期刊论文

作者Wang, Meng2,4; Zhang, Peiwei2,4; Zhu, Yufei2,4; Kong, Xiangyin2,4; Hu, Landian2,4; Zhang, Zhenguo1,3; ,
刊名BMC MEDICAL GENOMICS
出版日期2017
卷号10期号:-页码:55
关键词Lung adenocarcinoma Cancer therapy Tumor growth suppression Nonsense-mediated mRNA decay
ISSN号1755-8794
DOI10.1186/s12920-017-0292-z
文献子类Article
英文摘要Background: Inhibition of nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by NMD. Thus NMD inhibition is a promising approach for developing cancer therapies. Apparently, the success of this approach relies on the basal NMD activity in cancer cells. If NMD is already strongly inhibited in tumors, the approach would not work. Therefore, it is crucial to assess NMD activity in cancers to forecast the efficacy of NMD-inhibition based therapy. Methods: Here we develop three metrics using RNA-seq data to measure NMD activity, and apply them to a dataset consisting of 72 lung cancer (adenocarcinoma) patients. Results: We show that these metrics have good correlations, and that the NMD activities in adenocarcinoma samples vary among patients: some cancerous samples show significantly stronger NMD activities than the normal tissues while some others show the opposite pattern. The variation of NMD activities among these samples may be partly explained by the varying expression of NMD effectors. Conclusions: In sum, NMD activity varies among lung cancerous samples, which forecasts varying efficacies of NMD-inhibition based therapy. The developed metrics can be further used in other cancer types to assess NMD activity.
学科主题Genetics & Heredity
WOS关键词HUMAN-CELLS ; INHIBITION ; NMD ; EXPRESSION ; PATHWAY ; GENE
语种英语
WOS记录号WOS:000409246600001
出版者BIOMED CENTRAL LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/892]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Univ Rochester, Dept Biol, Rochester, NY 14627 USA;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Med Genom, Inst Hlth Sci, Shanghai, Peoples R China;
3.17062 Murphy Ave, Irvine, CA 92614 USA,
4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Meng,Zhang, Peiwei,Zhu, Yufei,et al. Assessing the activity of nonsense-mediated mRNA decay in lung cancer[J]. BMC MEDICAL GENOMICS,2017,10(-):55.
APA Wang, Meng.,Zhang, Peiwei.,Zhu, Yufei.,Kong, Xiangyin.,Hu, Landian.,...&,.(2017).Assessing the activity of nonsense-mediated mRNA decay in lung cancer.BMC MEDICAL GENOMICS,10(-),55.
MLA Wang, Meng,et al."Assessing the activity of nonsense-mediated mRNA decay in lung cancer".BMC MEDICAL GENOMICS 10.-(2017):55.

入库方式： OAI收割

来源：上海营养与健康研究所

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