Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
文献类型：期刊论文
| 作者 | Haycock, Philip C.29,30; Nounu, Aayah30; Zheng, Jie29,30; Bowden, Jack29,30; Paternoster, Lavinia29,30; Relton, Caroline L.29,30; Martin, Richard M.29,30; Smith, George Davey29,30; Okoli, George N.29; Wade, Kaitlin Hazel29 |
| 刊名 | JAMA ONCOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 3期号:5页码:636-651 |
| ISSN号 | 2374-2437 |
| 关键词 | CTLA-4 Psoriasis T cells Mouse model of psoriasis |
| DOI | 10.1001/jamaoncol.2016.5945 |
| 文献子类 | Article |
| 英文摘要 | IMPORTANCE The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases. |
| 学科主题 | Oncology |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; ABDOMINAL AORTIC-ANEURYSM ; INCIDENT COLORECTAL-CARCINOMA ; MULTIPLE SUSCEPTIBILITY LOCI ; PERIPHERAL-BLOOD LEUKOCYTES ; NONMELANOMA SKIN-CANCER ; SQUAMOUS-CELL CARCINOMA ; SHANGHAI WOMENS HEALTH ; LUNG-CANCER ; ENDOMETRIAL CANCER |
| 语种 | 英语 |
| 出版者 | AMER MEDICAL ASSOC |
| WOS记录号 | WOS:000401114700011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/895]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Bonn, Inst Human Genet, Bonn, Germany; 2.Univ Toronto, Dept Mol, Toronto, ON, Canada; 3.Univ Toronto, Dept Immunol, Toronto, ON, Canada; 4.Univ Toronto, Dept Med, Toronto, ON, Canada; 5.NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA; 6.QIMR Berghofer Med Res Inst, Genet & Computat Biol Div, Brisbane, Qld, Australia; 7.Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA; 8.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada; 9.Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada; 10.Univ Cambridge, Dept Clin Neurosci, Cambridge, England; |
| 推荐引用方式 GB/T 7714 | Haycock, Philip C.,Nounu, Aayah,Zheng, Jie,et al. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study[J]. JAMA ONCOLOGY,2017,3(5):636-651. |
| APA | Haycock, Philip C..,Nounu, Aayah.,Zheng, Jie.,Bowden, Jack.,Paternoster, Lavinia.,...&,.(2017).Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study.JAMA ONCOLOGY,3(5),636-651. |
| MLA | Haycock, Philip C.,et al."Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study".JAMA ONCOLOGY 3.5(2017):636-651. |
入库方式： OAI收割
来源：上海营养与健康研究所
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