Association of a Gain-of-Function Variant in LGR4 with Central Obesity
文献类型：期刊论文
| 作者 | Zou, Yaoyu4,5; Ning, Tinglu4,5; Ning, Guang4,5,6; Wang, Jiqiu4,5,6; Shi, Juan6; Chen, Maopei6; Ding, Lin6; Huang, Ya6; Xu, Min6; Cui, Bin6 |
| 刊名 | OBESITY
 |
| 出版日期 | 2017 |
| 卷号 | 25期号:1页码:252-260 |
| 关键词 | Structured sparse clustering K-means clustering Feature selection Graph Laplacian smoothing |
| ISSN号 | 1930-7381 |
| DOI | 10.1002/oby.21704 |
| 文献子类 | Article |
| 英文摘要 | Objective: To determine the relationship of the gain-of-function variant A750T in leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) with central obesity and related metabolic phenotypes. Methods: The LGR4 A750T (c. 2248 G > A) variant was detected by Sanger sequencing in a discovery young population and a validation community-based population with obesity from eastern China. Fat indices determined by anthropometry and computed tomography scans and clinical biochemical measurements were collected for association analysis. Results: LGR4 A750T was significantly correlated with waist circumference (P = 0.030) and waist-to-height ratio (P < 0.001) in the young cohort (N = 594) and with waist-to-hip ratio (P 5 0.013) in the community population (N = 1067). Combined analysis showed a significant correlation of the variant with waist circumference (P < 0.001) and waist-to-hip ratio (P = 0.021). Moreover, the variant had a remarkable correlation with abdominal visceral fat area (P = 0.004) and was associated with 2-h plasma insulin (P = 0.009) and the Matsuda index (P = 0.027) after an oral glucose tolerance test in young subjects with obesity. Conclusions: The LGR4 A750T variant may contribute to central obesity characterized by abdominal visceral fat accumulation. |
| 学科主题 | Endocrinology & Metabolism ; Nutrition & Dietetics |
| WOS关键词 | WAIST CIRCUMFERENCE ; ABDOMINAL OBESITY ; CARDIOVASCULAR-DISEASE ; INSULIN SENSITIVITY ; METABOLIC SYNDROME ; RISK ; GLUCOSE ; RESISTANCE ; ABLATION ; HEALTH |
| 语种 | 英语 |
| WOS记录号 | WOS:000391215200032 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/896]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Brown Univ, Dept Med Endocrinol, Warren Alpert Med Sch, Providence, RI 02912 USA, 2.Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA; 3.Brown Univ, Sch Publ Hlth, Ctr Global Cardiometab Hlth, Providence, RI 02912 USA; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis,Shanghai, Natl Key Lab Med Genomes,Dept Endocrinol & Metab, China Natl Res Ctr Metab Dis,Ruijin Hosp,Sch Med, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zou, Yaoyu,Ning, Tinglu,Ning, Guang,et al. Association of a Gain-of-Function Variant in LGR4 with Central Obesity[J]. OBESITY,2017,25(1):252-260. |
| APA | Zou, Yaoyu.,Ning, Tinglu.,Ning, Guang.,Wang, Jiqiu.,Shi, Juan.,...&,.(2017).Association of a Gain-of-Function Variant in LGR4 with Central Obesity.OBESITY,25(1),252-260. |
| MLA | Zou, Yaoyu,et al."Association of a Gain-of-Function Variant in LGR4 with Central Obesity".OBESITY 25.1(2017):252-260. |
入库方式： OAI收割
来源：上海营养与健康研究所
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