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Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population

文献类型：期刊论文

作者Yang, Beimeng1,4; Niu, Weibo1,4; Chen, Shiqing1,4; Xu, Fei1,4; Li, Xingwang1,4; Wu, Xi1,4; Cao, Yanfei1,4; Zhang, Rui1,4; Yang, Fengping1,4; Wang, Lu1,4
刊名PSYCHIATRIC GENETICS
出版日期2017
卷号27期号:2页码:76-77
ISSN号0955-8829
关键词poly IC B cell systemic lupus erythematosus Peli1 noncanonical NF-kappa B
DOI10.1097/YPG.0000000000000160
文献子类Editorial Material
英文摘要Noncanonical NF-kappa B pathway is essential for the B cell activation and antibody production, which centralize the critical role of B cells in regulating the pathogenesis of systemic lupus erythematosus (SLE). We have previously demonstrated that Pellinol (Peli1) negatively regulates noncanonical NF-kappa B activation and lupus autoimmunity. Here, we showed that poly IC is a potent inducer of Peli1 protein in mouse splenic B cells in dose- and time-dependent manners, and poly IC-induced Peli1 protein dramatically suppressed the activation of noncanonical NF-kappa B pathway. In addition, poly IC-pretreated B cells failed to induce lupus-like disease in BM12 CD4(+) T cell-immunized mice. Accordingly, the induction of antibody-producing plasma cells and germinal center B cells, as well as the production of autoantibodies were significantly impaired in immunized mu MT mice that were transferred with poly IC-pretreated B cells. Our findings demonstrate that poly IC-induced Peli1 negatively regulates the noncanonical NF-kappa B pathway in the context of restraining the pathogenesis of lupus-like disease.
学科主题Genetics & Heredity ; Neurosciences & Neurology
WOS关键词DISEASE
语种英语
出版者LIPPINCOTT WILLIAMS & WILKINS
WOS记录号WOS:000394538700005
版本出版稿
源URL[http://202.127.25.144/handle/331004/897]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China;
2.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Beijing 100864, Peoples R China;
3.Wuxi Mental Hlth Ctr, Wuxi, Peoples R China,
4.Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai Key Lab Psychot Disorders, Bio X Inst,Minist Educ, Shanghai 200030, Peoples R China;
推荐引用方式
GB/T 7714		 Yang, Beimeng,Niu, Weibo,Chen, Shiqing,et al. Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population[J]. PSYCHIATRIC GENETICS,2017,27(2):76-77.
APA Yang, Beimeng.,Niu, Weibo.,Chen, Shiqing.,Xu, Fei.,Li, Xingwang.,...&,.(2017).Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population.PSYCHIATRIC GENETICS,27(2),76-77.
MLA Yang, Beimeng,et al."Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population".PSYCHIATRIC GENETICS 27.2(2017):76-77.

入库方式： OAI收割

来源：上海营养与健康研究所

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