中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population

文献类型：期刊论文

作者Yang, Beimeng1,4; Niu, Weibo1,4; Chen, Shiqing1,4; Xu, Fei1,4; Li, Xingwang1,4; Wu, Xi1,4; Cao, Yanfei1,4; Zhang, Rui1,4; Yang, Fengping1,4; Wang, Lu1,4
刊名PSYCHIATRIC GENETICS
出版日期2017
卷号27期号:2页码:76-77
关键词poly IC B cell systemic lupus erythematosus Peli1 noncanonical NF-kappa B
ISSN号0955-8829
DOI10.1097/YPG.0000000000000160
文献子类Editorial Material
英文摘要Noncanonical NF-kappa B pathway is essential for the B cell activation and antibody production, which centralize the critical role of B cells in regulating the pathogenesis of systemic lupus erythematosus (SLE). We have previously demonstrated that Pellinol (Peli1) negatively regulates noncanonical NF-kappa B activation and lupus autoimmunity. Here, we showed that poly IC is a potent inducer of Peli1 protein in mouse splenic B cells in dose- and time-dependent manners, and poly IC-induced Peli1 protein dramatically suppressed the activation of noncanonical NF-kappa B pathway. In addition, poly IC-pretreated B cells failed to induce lupus-like disease in BM12 CD4(+) T cell-immunized mice. Accordingly, the induction of antibody-producing plasma cells and germinal center B cells, as well as the production of autoantibodies were significantly impaired in immunized mu MT mice that were transferred with poly IC-pretreated B cells. Our findings demonstrate that poly IC-induced Peli1 negatively regulates the noncanonical NF-kappa B pathway in the context of restraining the pathogenesis of lupus-like disease.
学科主题Genetics & Heredity ; Neurosciences & Neurology
WOS关键词DISEASE
语种英语
WOS记录号WOS:000394538700005
出版者LIPPINCOTT WILLIAMS & WILKINS
版本出版稿
源URL[http://202.127.25.144/handle/331004/897]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China;
2.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Beijing 100864, Peoples R China;
3.Wuxi Mental Hlth Ctr, Wuxi, Peoples R China,
4.Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai Key Lab Psychot Disorders, Bio X Inst,Minist Educ, Shanghai 200030, Peoples R China;
推荐引用方式
GB/T 7714		 Yang, Beimeng,Niu, Weibo,Chen, Shiqing,et al. Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population[J]. PSYCHIATRIC GENETICS,2017,27(2):76-77.
APA Yang, Beimeng.,Niu, Weibo.,Chen, Shiqing.,Xu, Fei.,Li, Xingwang.,...&,.(2017).Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population.PSYCHIATRIC GENETICS,27(2),76-77.
MLA Yang, Beimeng,et al."Association study of the GLRX5 rs1007814 polymorphism with schizophrenia in the Han Chinese population".PSYCHIATRIC GENETICS 27.2(2017):76-77.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。