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Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

文献类型：期刊论文

作者Li, Chenguang3; Wang, Jing3; Shu, Bing3; Wang, Yongjun3; Chen, Peizhan2,4; Li, Xiaoguang2,4; Ba, Qian2,4; Li, Jingquan2,4; Wang, Hui2,4; Duan, Xiaohua4
刊名EBIOMEDICINE
出版日期2017
卷号15期号:-页码:184-192
关键词Total 25(OH)D Bioavailable 25(OH)D Bone mineral density Bone turnover biomarkers Postmenopausal women
ISSN号2352-3964
DOI10.1016/j.ebiom.2016.11.029
文献子类Article
英文摘要Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. Whether bioavailable 25(OH)D level is a superior biomarker for vitamin D than total 25(OH)D level regarding the BMD and the bone metabolism were not yet fully understood. With a community based cross-sectional study of 967 postmenopausal women, we found that the variant rs7041, but not rs4588, of DBP was significantly associated with the blood DBP level, which was positively correlated with the total 25(OH)D level but negatively associated with bioavailable 25(OH)D levels. Both total and bioavailable 25(OH)D levels were significantly correlated with the BMD value in postmenopausal women; however, only the bioavailable 25(OH)D level was an independent determinant of the BMD values when adjusted for age, body mass index and bone turnover biomarkers (OST and beta-CTX). The bioavailable and total 25(OH)D were negatively correlated with bone formation biomarkers (OST, PINP and ALP) and PTH levels, while they were positively correlated with osteoprotegerin (OPG) level; however, the bone resorption biomarker (beta-CTX) was not correlated with the 25(OH)D levels. An increment of PTH level, along with reduced bioavailable 25(OH)D levels, was evident when the bioavailable 25(OH)D level was <5 ng/mL, which may be the optimal cutpoint for sufficient vitamin D in Chinese elderly women. The blood calcium, magnesium, ALP, TSH, FGF23, and phosphorus levels were not correlated with the total or the bioavailable 25(OH)D levels. These results suggested that high bioavailable 25(OH)D levels were correlated with reduced bone turnover processes and were a biomarker superior to total 25(OH)D for vitamin D in assessing the risks of bone-related diseases. The results indicate that the bioavailable 25(OH)D level should be determined in assessing the bone health. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
学科主题General & Internal Medicine ; Research & Experimental Medicine
WOS关键词VITAMIN-D STATUS ; PARATHYROID-HORMONE LEVELS ; D-BINDING PROTEIN ; BODY-MASS INDEX ; 25-HYDROXYVITAMIN D ; SERUM ; ASSOCIATIONS ; OSTEOPOROSIS ; TURNOVER ; FRACTURE
语种英语
WOS记录号WOS:000395258200022
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/898]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Univ Tradit Chinese Med, Rehabil Sch, Shanghai 200032, Peoples R China;
2.Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, 227 South Chongqing Rd, Shanghai 200025, Peoples R China;
3.Shanghai Univ Tradit Chinese Med, Longhua Hosp, 725 Wan Ping South Rd, Shanghai 200032, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai 200031, Peoples R China;
5.Chinese Acad Sci, Shanghai Clin Ctr, Shanghai 200031, Peoples R China,
推荐引用方式
GB/T 7714		 Li, Chenguang,Wang, Jing,Shu, Bing,et al. Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women[J]. EBIOMEDICINE,2017,15(-):184-192.
APA Li, Chenguang.,Wang, Jing.,Shu, Bing.,Wang, Yongjun.,Chen, Peizhan.,...&,.(2017).Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women.EBIOMEDICINE,15(-),184-192.
MLA Li, Chenguang,et al."Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women".EBIOMEDICINE 15.-(2017):184-192.

入库方式： OAI收割

来源：上海营养与健康研究所

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