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Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

文献类型：期刊论文

作者Yao, Yikun2,3,4; Wang, Feng2; Qian, Youcun2,3,4; Chen, Siyuan3,4; Cao, Mengtao3,4; Fan, Xing3,4; Yang, Tao3,4; Huang, Yin3,4; Song, Xinyang3,4; Li, Yongqin3,4
刊名NATURE COMMUNICATIONS
出版日期2017
卷号8期号:-页码:15402
关键词mouse bone marrow myeloid cell proliferation cytokine c-KIT Fpr2 Lin(-)c-Kit(+)Sca1(+)cells SCF
ISSN号2041-1723
DOI10.1038/ncomms15402
文献子类Article
英文摘要The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1 beta maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.
学科主题Science & Technology - Other Topics
WOS关键词VERSUS-HOST-DISEASE ; PATTERN-RECOGNITION RECEPTORS ; C2 DOMAIN ; MEDIATED CYTOTOXICITY ; METABOLIC DISEASE ; RESPONSES ; DIFFERENTIATION ; TRANSPLANTATION ; MECHANISMS ; IL-1-BETA
语种英语
WOS记录号WOS:000401959900001
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/899]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Renji Hosp, Shanghai Inst Rheumatol, Shanghai 200001, Peoples R China;
2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Nephrol, Shanghai 200233, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, CAS Ctr Excellence Mol Cell Sci,Key Lab Stem Cell, Shanghai 200031, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China;
5.Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China;
6.Cleveland Clin Fdn, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USA,
推荐引用方式
GB/T 7714		 Yao, Yikun,Wang, Feng,Qian, Youcun,et al. Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin[J]. NATURE COMMUNICATIONS,2017,8(-):15402.
APA Yao, Yikun.,Wang, Feng.,Qian, Youcun.,Chen, Siyuan.,Cao, Mengtao.,...&,.(2017).Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.NATURE COMMUNICATIONS,8(-),15402.
MLA Yao, Yikun,et al."Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin".NATURE COMMUNICATIONS 8.-(2017):15402.

入库方式： OAI收割

来源：上海营养与健康研究所

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