Bipotent progenitors as embryonic origin of retinal stem cells
文献类型：期刊论文
| 作者 | Tang, Xia2; Gao, Jianan2; Jia, Xinling2; Zhang, Yijie2; He, Jie2; Zhao, Wencao1,3; Pan, Weijun1,3; , |
| 刊名 | JOURNAL OF CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 216期号:6页码:1833-1847 |
| 关键词 | osteoarthritis blood gene expression signature support vector machine minimal redundancy maximal relevance incremental feature selection |
| ISSN号 | 0021-9525 |
| DOI | 10.1083/jcb.201611057 |
| 文献子类 | Article |
| 英文摘要 | In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification. |
| 学科主题 | Cell Biology |
| WOS关键词 | CILIARY MARGINAL ZONE ; ADULT MAMMALIAN EYE ; VERTEBRATE RETINA ; VASCULAR NICHE ; ZEBRAFISH RETINA ; GANGLION-CELLS ; MULTIPOTENT PRECURSORS ; NEURAL PROGENITORS ; XENOPUS RETINA ; VISUAL-SYSTEM |
| 语种 | 英语 |
| WOS记录号 | WOS:000402702500029 |
| 出版者 | ROCKEFELLER UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/900]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai Inst Biol Sci, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Tang, Xia,Gao, Jianan,Jia, Xinling,et al. Bipotent progenitors as embryonic origin of retinal stem cells[J]. JOURNAL OF CELL BIOLOGY,2017,216(6):1833-1847. |
| APA | Tang, Xia.,Gao, Jianan.,Jia, Xinling.,Zhang, Yijie.,He, Jie.,...&,.(2017).Bipotent progenitors as embryonic origin of retinal stem cells.JOURNAL OF CELL BIOLOGY,216(6),1833-1847. |
| MLA | Tang, Xia,et al."Bipotent progenitors as embryonic origin of retinal stem cells".JOURNAL OF CELL BIOLOGY 216.6(2017):1833-1847. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。