Antioxidant MMCC ameliorates catch-up growth related metabolic dysfunction
文献类型:期刊论文
作者 | Ju, Liping2; Tong, Wenxin2; Qiu, Miaoyan2; Zheng, Sheng2; Chen, Ying2; Tian, Jingyan2,3; Tong, Wenxin3; Shen, Weili4; Sun, Jichao1,5; Liu, Wentao6 |
刊名 | ONCOTARGET
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出版日期 | 2017 |
卷号 | 8期号:59页码:99931-99939 |
关键词 | catch-up growth MMCC (MitoQuinone mesylate beta cyclodextrin complex) mitochondria metabolic dysfunction skeletal functions |
ISSN号 | 1949-2553 |
DOI | 10.18632/oncotarget.21965 |
文献子类 | Article |
英文摘要 | Postnatal catch-up growth may be related to reduce mitochondrial content and oxidation capacity in skeletal muscle. The aim of this study is to explore the effect and mechanism of antioxidant MitoQuinone mesylate beta cyclodextrin complex (MMCC) ameliorates catch-up growth related metabolic disorders. Catch-up growth mice were created by restricting maternal food intake during the last week of gestation and providing high fat diet after weaning. Low birthweight mice and normal birthweight controls were randomly subjected to normal fat diet, high fat diet and high fat diet with MMCC drinking from the 4th week. MMCC treatment for 21 weeks slowed down the catch up growth and ameliorated catch-up growth related obesity, glucose intolerance and insulin resistance. MMCC administration significantly inhibited the peroxidation of the membrane lipid and up-regulated the antioxidant enzymes Catalase and MnSOD. In addition, MMCC treatment effectively enhanced mitochondrial functions in skeletal muscle through the up-regulation of the ATP generation, and the promotion of mitochondrial replication and remodeling. To conclude, this study demonstrates that antioxidant MMCC effectively ameliorates catch-up growth related metabolic dysfunctions by increasing mitochondrial functions in skeletal muscle. |
学科主题 | Oncology ; Cell Biology |
WOS关键词 | LOW-BIRTH-WEIGHT ; SKELETAL-MUSCLE ; ADULT HEALTH ; MITOCHONDRIA ; EXERCISE ; WATER ; FAT ; UNDERNUTRITION ; ORIGINS ; DISEASE |
语种 | 英语 |
WOS记录号 | WOS:000419561600065 |
出版者 | IMPACT JOURNALS LLC |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/902] ![]() |
专题 | 中国科学院上海生命科学研究院营养科学研究所 |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Ruijin Hosp,Sch Med, Shanghai Clin Ctr Endocrine & Metab Dis,Dept Endo, Shanghai, Peoples R China; 3.City Hope Natl Med Ctr, Dept Diabet Complicat & Metab, Beckman Res Inst, Duarte, CA 91010 USA; 4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hypertens, Shanghai, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrine & Metab Dis, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Shanghai Inst Digest Surg, Dept Surg, Key Lab Shanghai Gastr Neoplasms,Ruijin Hosp, Shanghai, Peoples R China, |
推荐引用方式 GB/T 7714 | Ju, Liping,Tong, Wenxin,Qiu, Miaoyan,et al. Antioxidant MMCC ameliorates catch-up growth related metabolic dysfunction[J]. ONCOTARGET,2017,8(59):99931-99939. |
APA | Ju, Liping.,Tong, Wenxin.,Qiu, Miaoyan.,Zheng, Sheng.,Chen, Ying.,...&,.(2017).Antioxidant MMCC ameliorates catch-up growth related metabolic dysfunction.ONCOTARGET,8(59),99931-99939. |
MLA | Ju, Liping,et al."Antioxidant MMCC ameliorates catch-up growth related metabolic dysfunction".ONCOTARGET 8.59(2017):99931-99939. |
入库方式: OAI收割
来源:上海营养与健康研究所
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