Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort
文献类型：期刊论文
| 作者 | Simpkin, Andrew J.5,6; Howe, Laura D.6; Relton, Caroline L.6; Smith, George Davey6; Cooper, Rachel1; Wong, Andrew1; Kuh, Diana1; Hardy, Rebecca1; Teschendorff, Andrew2,3,4; Widschwendter, Martin2 |
| 刊名 | BMJ OPEN
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:10页码:e016708 |
| ISSN号 | 2044-6055 |
| 关键词 | TiO2 nanoparticles Macrophages Mitochondrial dysfunction Inflammation Proteomics Metabolomics |
| DOI | 10.1136/bmjopen-2017-016708 |
| 文献子类 | Article |
| 英文摘要 | Objectives Our aim was to investigate the association of epigenetic age and physical capability in later life. Having a higher epigenetic than chronological age (known as age acceleration (AA)) has been found to be associated with an increased rate of mortality. Similarly, physical capability has been proposed as a marker of ageing due to its consistent associations with mortality. Setting The MRC National Survey of Health and Development (NSHD) cohort study. Participants We used data from 790 women from the NSHD who had DNA methylation data available. Design Epigenetic age was calculated using buccal cell (n=790) and matched blood tissue (n=152) from 790 female NSHD participants. We investigated the association of AA at age 53 with changes in physical capability in women from ages 53 to 60-64. Regression models of change in each measure of physical capability on AA were conducted. Secondary analysis focused on the relationship between AA and smoking, alcohol, body mass index (BMI) and socioeconomic position. Outcome measures Three objective measures of physical capability were used: grip strength, standing balance time and chair rise speed. Results Epigenetic age was lower than chronological age (mean 53.4) for both blood (50.3) and buccal cells (42.8). AA from blood was associated with a greater decrease in grip strength from ages 53 to 60-64 (0.42 kg decrease per year of AA, 95% CI 0.03, 0.82 kg; p=0.03, n=152), but no associations were observed with standing balance time or chair rise speed. Current smoking and lower BMI were associated with lower epigenetic age from buccal cells. Conclusions We found evidence that AA in blood is associated with a greater decrease in grip strength in British females aged between 53 and 60-64, but no association with standing balance time or chair rise speed was found. |
| 学科主题 | General & Internal Medicine |
| WOS关键词 | DNA METHYLATION AGE ; MORTALITY ; ASSOCIATIONS ; MICROARRAYS ; CHILDREN ; SMOKING ; OBESITY ; PROFILE ; HEALTH ; LIFE |
| 语种 | 英语 |
| 出版者 | BMJ PUBLISHING GROUP |
| WOS记录号 | WOS:000422617500100 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/904]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.UCL, MRC Unit Lifelong Hlth & Ageing, London, England; 2.UCL, Dept Womens Canc, London, England; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China; 4.UCL, UCL Canc Inst, Dept Stat Canc Genom, London, England; 5.Natl Univ Ireland, Insight Ctr Data Analyt, Galway, Ireland, 6.Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England; |
| 推荐引用方式 GB/T 7714 | Simpkin, Andrew J.,Howe, Laura D.,Relton, Caroline L.,et al. Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort[J]. BMJ OPEN,2017,7(10):e016708. |
| APA | Simpkin, Andrew J..,Howe, Laura D..,Relton, Caroline L..,Smith, George Davey.,Cooper, Rachel.,...&,.(2017).Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort.BMJ OPEN,7(10),e016708. |
| MLA | Simpkin, Andrew J.,et al."Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort".BMJ OPEN 7.10(2017):e016708. |
入库方式： OAI收割
来源：上海营养与健康研究所
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