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Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

文献类型：期刊论文

作者Tang, Yun-Chi1,8; Hui Yuwen1,8; Zhong, Na1,8; Wang, Kaiying1; Huang, Tao1,2; Wang, Lan1,2; Wang, Kaiying2; Bruno, Peter M.3,4; Santaguida, Stefano3; Trakala, Marianna3,6,7
刊名CANCER RESEARCH
出版日期2017
卷号77期号:19页码:5272-5286
关键词cell lineage myocardial infarction myocardial revascularization myocytes cardiac recombinases stem cell
ISSN号0008-5472
DOI10.1158/0008-5472.CAN-17-0049
文献子类Article
英文摘要Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide monohydrochloride (DL-PDMP), an antagonist of UDP-glucose ceramide glucosyltransferase. DL-PDMP selectively inhibited proliferation of aneuploid primary mouse embryonic fibroblasts and aneuploid colorectal cancer cells. Its selective cytotoxic effects were based on further accentuating the elevated levels of ceramide, which characterize aneuploid cells, leading to increased apoptosis. We observed that DL-PDMP could also enhance the cytotoxic effects of paclitaxel, a standard-of-care chemotherapeutic agent that causes aneuploidy, in human colon cancer and mouse lymphoma cells. Our results offer pharmacologic evidence that the aneuploid state in cancer cells can be targeted selectively for therapeutic purposes, or for reducing the toxicity of taxane-based drug regimens. (C) 2017 AACR.
学科主题Oncology
WOS关键词CHROMOSOMAL INSTABILITY ; GLUCOSYLCERAMIDE SYNTHASE ; PROTEOTOXIC STRESS ; COLORECTAL-CANCER ; INDUCED APOPTOSIS ; DRUG MECHANISMS ; COLON-CANCER ; DNA-DAMAGE ; YEAST ; PRINCIPLES
语种英语
WOS记录号WOS:000412138300007
出版者AMER ASSOC CANCER RESEARCH
版本出版稿
源URL[http://202.127.25.144/handle/331004/905]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China;
3.MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA;
4.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA;
5.Broad Inst MIT & Harvard, Metabol Platform, Cambridge, MA USA;
6.MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA;
7.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA,
8.Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Key Lab Stem Cell Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Tang, Yun-Chi,Hui Yuwen,Zhong, Na,et al. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis[J]. CANCER RESEARCH,2017,77(19):5272-5286.
APA Tang, Yun-Chi.,Hui Yuwen.,Zhong, Na.,Wang, Kaiying.,Huang, Tao.,...&,.(2017).Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.CANCER RESEARCH,77(19),5272-5286.
MLA Tang, Yun-Chi,et al."Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis".CANCER RESEARCH 77.19(2017):5272-5286.

入库方式： OAI收割

来源：上海营养与健康研究所

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