Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
文献类型：期刊论文
| 作者 | Li, Qian1,2; Xu, Chuan1,2; Guo, Yanan1,2; Sun, Jing1; Khaitovich, Philipp1,4; Bozek, Katarzyna3; Paabo, Svante4; Sherwood, Chet C.5,6; Hof, Patrick R.7,8; Ely, John J.9 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2017 |
| 卷号 | 34期号:5页码:1155-1166 |
| 关键词 | lipidome brain development evolution |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msx065 |
| 文献子类 | Article |
| 英文摘要 | Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | PREFRONTAL CORTEX ; EVOLUTION ; GLYCOSYNAPSE ; DIVERSITY ; TISSUES ; AGE |
| 语种 | 英语 |
| WOS记录号 | WOS:000399373300010 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/906]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China; 3.Okinawa Inst Sci & Technol, Okinawa, Japan; 4.Max Planck Inst Evolutionary Anthropol, Leipzig, Germany; 5.George Washington Univ, Dept Anthropol, Washington, DC USA; 6.George Washington Univ, Ctr Adv Study Human Paleobiol, Washington, DC USA; 7.Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA; 8.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA; 9.MAEBIOS, Alamogordo, NM USA; 10.Max Planck Inst Mol Plant Physiol, Potsdam, Germany; |
| 推荐引用方式 GB/T 7714 | Li, Qian,Xu, Chuan,Guo, Yanan,et al. Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys[J]. MOLECULAR BIOLOGY AND EVOLUTION,2017,34(5):1155-1166. |
| APA | Li, Qian.,Xu, Chuan.,Guo, Yanan.,Sun, Jing.,Khaitovich, Philipp.,...&,.(2017).Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys.MOLECULAR BIOLOGY AND EVOLUTION,34(5),1155-1166. |
| MLA | Li, Qian,et al."Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys".MOLECULAR BIOLOGY AND EVOLUTION 34.5(2017):1155-1166. |
入库方式： OAI收割
来源：上海营养与健康研究所
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