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Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs

文献类型：期刊论文

作者He, Yu Hu1,2; Wang, Xiao Qun1,2; Liu, Zhu Hui1,2; Pan, Wen Qi2; Shen, Ying2; Zhu, Zheng Bin2; Wang, Ling Jie1,2; Yan, Xiao Xiang1,2; Zhang, Rui Yan2; Shen, Wei Feng1,2
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
出版日期2017
卷号37期号:4页码:717-729
关键词HMGB2 in-stent restenosis neointimal hyperplasia p47phox ROS
ISSN号1079-5642
DOI10.1161/ATVBAHA.116.308210
文献子类Article
英文摘要Objective-In a previous study, we established diabetic and nondiabetic minipig models with coronary artery in-stent restenosis (ISR). Mass spectrometry showed that high-mobility group box (HMGB) 2 level was higher in ISR than in non-ISR tissue from diabetic minipigs. We here investigated whether serum HMGB2 levels were related to ISR in coronary artery disease patients. The effect of HMGB2 was evaluated in mice with femoral artery wire injury and in human aortic smooth muscle cells. Approach and Results-From 2513 patients undergoing coronary artery intervention and follow-up angiography at approximate to 1 year, 262 patients were diagnosed with ISR, and 298 patients with no ISR were randomly included as controls. Serum HMGB2 levels were significantly higher in patients with ISR than in those without ISR and were associated with ISR severity. Multivariable logistic regression analysis showed that HMGB2 level was independently associated with ISR. In experiments, HMGB2 expression was increased in vascular tissue after injury. Perivascular HMGB2 administration promoted injury-induced neointimal hyperplasia in C57Bl/6 mice compared with in the control, whereas such pathophysiological features were attenuated in Hmgb2(-/-) mice. Mechanistically, HMGB2 enhanced neointimal hyperplasia in mice and proliferation and migration in human aortic smooth muscle cells by inducing reactive oxygen species through increased p47phox phosphorylation. Knocking down p47phox, however, inhibited HMGB2-induced effects in human aortic smooth muscle cells. Finally, HMGB2-induced effects were significantly declined in receptor of advanced glycation end products knockdown or deficient cells, but not in Toll-like receptor 4 knockdown or deficient cells. Conclusions-Serum HMGB2 levels were associated with ISR in patients. HMGB2 promoted neointimal hyperplasia in mice with arterial wire injury through reactive oxygen species activation.
学科主题Hematology ; Cardiovascular System & Cardiology
WOS关键词NADPH OXIDASE ; INFLAMMATION ; NOX1 ; OVEREXPRESSION ; HYPERTENSION
语种英语
WOS记录号WOS:000398210000017
出版者LIPPINCOTT WILLIAMS & WILKINS
版本出版稿
源URL[http://202.127.25.144/handle/331004/907]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, Shanghai, Peoples R China;
2.Rui Jin Hosp, Dept Cardiol, 197 Rui Jin Rd 2, Shanghai 200025, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Beijing, Peoples R China,
推荐引用方式
GB/T 7714		 He, Yu Hu,Wang, Xiao Qun,Liu, Zhu Hui,et al. Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2017,37(4):717-729.
APA He, Yu Hu.,Wang, Xiao Qun.,Liu, Zhu Hui.,Pan, Wen Qi.,Shen, Ying.,...&,.(2017).Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,37(4),717-729.
MLA He, Yu Hu,et al."Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 37.4(2017):717-729.

入库方式： OAI收割

来源：上海营养与健康研究所

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