Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis
文献类型：期刊论文
| 作者 | Zheng, Chao1,7,8,9,10; Wang, Yuetong1,9,10; Yang, Liu1,9,10; Gao, Yijun1,9,10; Li, Fuming1,9,10; Feng, Yan1,9,10; Wang, Zuoyun1,9,10; Zhu, Xueliang1,9,10; Chen, Zhengjun1,9,10; Ji, Hongbin1,9,10 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:10407 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-10891-0 |
| 文献子类 | Article |
| 英文摘要 | Cell division cycle 42 (CDC42) plays important roles in polarity establishment and maintenance as well as cell cycle progression and cell division. Although disruption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumorigenesis are still poorly understood. Here we find that Cdc42 deficiency inhibits the KrasG12D-induced lung alveoli tumor formation, while conversely promotes bronchiole tumor formation in mice. Bronchial Cdc42 loss destroys contact inhibition potentially through cell polarity disruption, and results in increased tumor formation. In contrast, deletion of Cdc42 in alveoli cells prevents KrasG12D-induced cell proliferation, which leads to reduced tumor formation. Further analyses of clinical specimens uncover a significant positive correlation between CDC42 and type II alveolar epithelial cells marker SP-A, indicating the potential importance of CDC42 in this specific subset of lung cancer. Collectively, we identify the lineage-specific function of CDC42 in lung tumorigenesis potentially through the regulation of cell polarity integrity. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | EPITHELIAL-CELL ; RHO-GTPASES ; TUMOR-SUPPRESSOR ; POLARITY PROTEIN ; BREAST-TUMORS ; CDC42 GTPASES ; CANCER-CELLS ; BETA-CATENIN ; E-CADHERIN ; EXPRESSION |
| 语种 | 英语 |
| WOS记录号 | WOS:000408997700106 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/908]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China, 3.Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02115 USA; 4.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA; 5.Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China; 7.Chinese Acad Sci, Shanghai Sci Res Ctr, Shanghai 201204, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Natl Ctr Prot Sci Shanghai, Shanghai 200031, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China; 10.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zheng, Chao,Wang, Yuetong,Yang, Liu,et al. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis[J]. SCIENTIFIC REPORTS,2017,7(-):10407. |
| APA | Zheng, Chao.,Wang, Yuetong.,Yang, Liu.,Gao, Yijun.,Li, Fuming.,...&,.(2017).Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.SCIENTIFIC REPORTS,7(-),10407. |
| MLA | Zheng, Chao,et al."Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis".SCIENTIFIC REPORTS 7.-(2017):10407. |
入库方式： OAI收割
来源：上海营养与健康研究所
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