Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
文献类型：期刊论文
| 作者 | Yu, Xianjun1,2; Zhao, Qun1; Zhang, Xixi1; Zhang, Haiwei1; Liu, Yongbo1; Wu, Xiaoxia1; Li, Ming1; Li, Xiaoming1; Zhang, Haibing1; Zhang, Jingxuan2 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:40页码:67300-67314 |
| 关键词 | celastrol NLRP3 inflammasome inflammatory disease |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.18619 |
| 文献子类 | Article |
| 英文摘要 | Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1 beta secretion both in vitro and in vivo. Notably, interruption of ASC oligomerization and autophagy activation are involved in NLRP3 inflammasome inactivation by celastrol. Importantly, in vivo results indicate that celastrol attenuates NLRP3 inflammasome-dependent inflammation diseases via autophagy-related pathway. Our results thus reveal celastrol as an inhibitor of NLRP3 inflammasome, implying the potential for clinical use of celastrol in treatment of NLRP3 inflammasome-driven inflammatory diseases. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | NF-KAPPA-B ; INDUCED SEPTIC SHOCK ; METABOLIC-DISORDER ; OXIDATIVE STRESS ; NITRIC-OXIDE ; AUTOPHAGY ; COLITIS ; MICE ; PROTECTS ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000410790500042 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/910]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China; 2.Hubei Univ Med, Sch Basic Med Sci, Lab Inflammat & Mol Pharmacol, Shiyan 442000, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yu, Xianjun,Zhao, Qun,Zhang, Xixi,et al. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation[J]. ONCOTARGET,2017,8(40):67300-67314. |
| APA | Yu, Xianjun.,Zhao, Qun.,Zhang, Xixi.,Zhang, Haiwei.,Liu, Yongbo.,...&,.(2017).Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation.ONCOTARGET,8(40),67300-67314. |
| MLA | Yu, Xianjun,et al."Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation".ONCOTARGET 8.40(2017):67300-67314. |
入库方式： OAI收割
来源：上海营养与健康研究所
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