Cell-matrix signals specify bone endothelial cells during developmental osteogenesis
文献类型：期刊论文
| 作者 | Langen, Urs H.2,3; Pitulescu, Mara E.2,3; Kim, Jung Mo2,3; Sivaraj, Kishor K.2,3; Kusumbe, Anjali P.2,3; Singh, Amit1,2,3; Bixel, M. Gabriele2,3; Adams, Ralf H.2,3; Enriquez-Gasca, Rocio1; Vaquerizas, Juan M.1 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:3页码:189-201 |
| ISSN号 | 1465-7392 |
| 关键词 | Qishen granules heart failure quantitative pathway analysis decomposing formula Wenyang Yiqi Huoxue Qingre Jiedu |
| DOI | 10.1038/ncb3476 |
| 文献子类 | Article |
| 英文摘要 | Blood vessels in the mammalian skeletal system control bone formation and support haematopoiesis by generating local niche environments. While a specialized capillary subtype, termed type H, has been recently shown to couple angiogenesis and osteogenesis in adolescent, adult and ageing mice, little is known about the formation of specific endothelial cell populations during early developmental endochondral bone formation. Here, we report that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelial cell subpopulations. The differentiation and functional properties of bone endothelial cells require cell-matrix signalling interactions. Loss of endothelial integrin beta 1 leads to endothelial cell differentiation defects and impaired postnatal bone growth, which is, in part, phenocopied by endothelial cell-specific laminin alpha 5 mutants. Our work outlines fundamental principles of vessel formation and endothelial cell differentiation in the developing skeletal system. |
| 学科主题 | Cell Biology |
| WOS关键词 | REGULATES ANGIOGENESIS ; EXTRACELLULAR-MATRIX ; LIVER-REGENERATION ; ANGIOCRINE SIGNALS ; MICE LACKING ; VEGF ; BETA-1-INTEGRIN ; INTEGRIN ; LAMININ ; ANGIOPOIETIN-2 |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000395355500009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/911]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Max Planck Inst Mol Biomed, Res Grp Regulatory Genom, D-48149 Munster, Germany; 2.Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany; 3.Univ Munster, Fac Med, D-48149 Munster, Germany; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China, 5.Univ Munster, Inst Physiol Chem & Pathobiochem & Cells Mot Clus, D-48149 Munster, Germany; |
| 推荐引用方式 GB/T 7714 | Langen, Urs H.,Pitulescu, Mara E.,Kim, Jung Mo,et al. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis[J]. NATURE CELL BIOLOGY,2017,19(3):189-201. |
| APA | Langen, Urs H..,Pitulescu, Mara E..,Kim, Jung Mo.,Sivaraj, Kishor K..,Kusumbe, Anjali P..,...&,.(2017).Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.NATURE CELL BIOLOGY,19(3),189-201. |
| MLA | Langen, Urs H.,et al."Cell-matrix signals specify bone endothelial cells during developmental osteogenesis".NATURE CELL BIOLOGY 19.3(2017):189-201. |
入库方式： OAI收割
来源：上海营养与健康研究所
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