Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma
文献类型：期刊论文
| 作者 | Liu, Chenglin1; Li, Yixue1; Zhang, Yu-Hang5; Huang, Tao5; Deng, Qinfang4; Zhou, Songwen4; Li, Yixue2,3; Cai, Yu-Dong6; , |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2017 |
| 卷号 | -期号:-页码:3859582 |
| 关键词 | pancreatic neoplasm long non-coding RNA cancer upregulated drug resistance epithelial-mesenchymal transition protein kinase B extracellular-signal-regulated kinase |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2017/3859582 |
| 文献子类 | Article |
| 英文摘要 | The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and regulation of body homeostasis. The availability of multilevel expression data enables a comprehensive view of the regulatory network. In this study, we analyzed the coding and noncoding gene expression profiles of 301 patients with uterine corpus endometrial carcinoma (UCEC). A new method was proposed to construct a genome-wide integrative network based on variance inflation factor (VIF) regression method. The cross-regulation relations of mRNA, lncRNA, and miRNA were then selected based on clique-searching algorithm from the network, when any two molecules of the three were shown as interacting according to the integrative network. Such relation, which we call them RNA-lncRNA-miRNA triplet, demonstrated the complexity in transcriptome regulation process. Finally, six UCEC-related triplets were selected in which the mRNA participates in endometrial carcinoma pathway, such as CDH1 and TP53. The multi-type RNAs are proved to be cross-regulated as to each of the six triplets according to literature. All the triplets demonstrated the association with the initiation and progression of UCEC. Our method provides a comprehensive strategy for the investigation of transcriptome regulation mechanism. |
| 学科主题 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; LONG NONCODING RNA ; E-CADHERIN ; GENE-EXPRESSION ; DOWN-REGULATION ; GASTRIC-CANCER ; CELLS ; MIR-331-3P ; MUTATIONS ; MIGRATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000394867100001 |
| 出版者 | HINDAWI LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/915]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China; 2.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China; 4.Tongji Univ, Shanghai Pulm Hosp, Inst Canc, Dept Med Oncol,Med Sch, Shanghai 200433, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 6.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Chenglin,Li, Yixue,Zhang, Yu-Hang,et al. Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma[J]. BIOMED RESEARCH INTERNATIONAL,2017,-(-):3859582. |
| APA | Liu, Chenglin.,Li, Yixue.,Zhang, Yu-Hang.,Huang, Tao.,Deng, Qinfang.,...&,.(2017).Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma.BIOMED RESEARCH INTERNATIONAL,-(-),3859582. |
| MLA | Liu, Chenglin,et al."Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma".BIOMED RESEARCH INTERNATIONAL -.-(2017):3859582. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。