Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection
文献类型：期刊论文
| 作者 | Dong, Jian5; Bao, Junmin5; Feng, Rui5; Zhao, Zhiqing5; Lu, Qingsheng5; Li, Haiyan5; Zhou, Jian5; Jing, Zaiping5; Zhao, Zhiqing4; Jing, Qing3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:12784 |
| 关键词 | congenital heart defects total anomalous pulmonary venous connection whole-exome sequencing copy number variants pathogenesis |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-13104-w |
| 文献子类 | Article |
| 英文摘要 | Acute aortic dissection (AAD) is a catastrophic emergency with high mortality and misdiagnosis rate. We aimed to determine whether circulating microRNAs allow to distinguish AAD from healthy controls and chest pain patients without AAD (CP). Plasma microRNAs expression were determined in 103 participants, including 37 AAD patients, 26 chronic aortic dissection patients, 17 healthy volunteers, 23 patients without AAD. We selected 16 microRNAs from microarray screening as candidates for further testing via qRT-PCR. The results showed that plasma miR-15a in patients with AAD (n = 37) had significantly higher expression levels than it from control group (n = 40; P = 0.008). By receiver operating characteristic curve analysis, the sensitivity was 75.7%; the specificity was 82.5%; and the AUC was 0.761 for detection of AAD. Furthermore, 37 patients with AAD had significantly higher plasma expression levels of let-7b, miR-15a, miR-23a and hcmv-miR-US33-5p compared with 14 CP patients of 40 controls (P = 0.000, 0.000, 0.026 and 0.011, respectively). The corresponding sensitivity were 79.4%, 75.7%, 91.9% and 73.5%, respectively; the specificity were 92.9%, 100%, 85.7% and 85.7%, respectively; and the AUCs of these microRNAs were 0.887, 0.855, 0.925 and 0.815, respectively. These data indicate that plasma miR-15a and miR-23a have promising clinical value in diagnosing AAD. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | STENT-GRAFT PLACEMENT ; SMOOTH-MUSCLE MYOSIN ; D-DIMER ; INTERNATIONAL REGISTRY ; PROTEIN ; EXPERIENCE ; DISEASE ; IRAD |
| 语种 | 英语 |
| WOS记录号 | WOS:000412492400010 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/917]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China; 3.Second Mil Med Univ, Changhai Hosp, Dept Cardiol, Shanghai, Peoples R China; 4.Second Mil Med Univ, Changhai Hosp, Dept Surg, Shanghai, Peoples R China; 5.Second Mil Med Univ, Changhai Hosp, Dept Vasc Surg, Shanghai, Peoples R China; 6.Second Mil Med Univ, Dept Pharmacol, Shanghai 200433, Peoples R China, 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Nucle Acid & Mol Med, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Dong, Jian,Bao, Junmin,Feng, Rui,et al. Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection[J]. SCIENTIFIC REPORTS,2017,7(-):12784. |
| APA | Dong, Jian.,Bao, Junmin.,Feng, Rui.,Zhao, Zhiqing.,Lu, Qingsheng.,...&,.(2017).Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection.SCIENTIFIC REPORTS,7(-),12784. |
| MLA | Dong, Jian,et al."Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection".SCIENTIFIC REPORTS 7.-(2017):12784. |
入库方式： OAI收割
来源：上海营养与健康研究所
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