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Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population

文献类型：期刊论文

作者Ren, Decheng2,3; Bi, Yan2,3; Xu, Fei2,3; Niu, Weibo2,3; Zhang, Rui2,3; Hu, Jiaxin2,3; Guo, Zhenming2,3; Wu, Xi2,3; Cao, Yanfei2,3; Huang, Xiaoye2,3
刊名NEUROSCIENCE LETTERS
出版日期2017
卷号653期号:-页码:239-243
ISSN号0304-3940
关键词Association GRIK4 Major depressive disorder (MDD) Case-control study Chinese Han population
DOI10.1016/j.neulet.2017.05.071
文献子类Article
英文摘要Major depressive disorder (MDD) is a common and complex mental disorder. Recent studies found that genetic variants located in GRIK4, which encoded glutamate ionotropic receptor kainate type subunit 4, was associated with the MDD. In this study, we intended to investigate whether GRIK4 gene was associated with MDD. So five single nucleotide polymorphisms (SNPs) were selected and genotyped (rs79526501, rs11218016, rs4582985, rs6589847, rs56275759) in 568 MDD patients and 846 healthy controls from Chinese Han population. The results showed that rs56275759 demonstrated statistically significant differences between MDD patients and control subjects both in allelic frequencies (p value = 0.011) and genotypic frequencies (p value = 0.029). Rs4582985 was excluded from the further analysis for its deviation from the Hardy-Weinberg equilibrium. Strong linkage disequilibrium (LD) was found among rs11218016, rs6589847 and rs56275759, and this block was significantly associated with MDD. In summary, our results firstly indicated that rs56275759 of GRIK4 gene might be associated with MDD in Chinese Han population. (C) 2017 Published by Elsevier Ireland Ltd.
学科主题Neurosciences & Neurology
WOS关键词GAMMA-AMINOBUTYRIC-ACID ; METABOTROPIC ACTIONS ; KAINATE RECEPTORS ; BIPOLAR DISORDER ; GLUTAMATE ; POLYMORPHISM ; MODEL ; RISK ; MICE
语种英语
出版者ELSEVIER IRELAND LTD
WOS记录号WOS:000405153900039
版本出版稿
源URL[http://202.127.25.144/handle/331004/919]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
2.Shanghai Jiao Tong Univ, Shanghai Inst Mental Hlth, Shanghai Key Lab Psychot Disorders, 600 South Wan Ping Rd, Shanghai 200030, Peoples R China,
3.Shanghai Jiao Tong Univ, Minist Educ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, 1954 Huashan Rd, Shanghai 200030, Peoples R China;
推荐引用方式
GB/T 7714		 Ren, Decheng,Bi, Yan,Xu, Fei,et al. Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population[J]. NEUROSCIENCE LETTERS,2017,653(-):239-243.
APA Ren, Decheng.,Bi, Yan.,Xu, Fei.,Niu, Weibo.,Zhang, Rui.,...&,.(2017).Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population.NEUROSCIENCE LETTERS,653(-),239-243.
MLA Ren, Decheng,et al."Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population".NEUROSCIENCE LETTERS 653.-(2017):239-243.

入库方式： OAI收割

来源：上海营养与健康研究所

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