Complement-mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension
文献类型：期刊论文
| 作者 | Ruan, Cheng-Chao1,2,5,6; Ma, Yu1,5,6; Ge, Qian1,5,6; Zhu, Li-Min1,5,6; Zhang, Ying1,5,6; Kong, Ling-Ran1,5,6; Wu, Qi-Hong1,5,6; Zhu, Ding-Liang1,5,6; Gao, Ping-Jin1,2,5,6; Li, Yan4 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2017 |
| 卷号 | 31期号:3页码:1120-+ |
| 关键词 | perivascular adipose tissue macrophage adipocyte |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201600780R |
| 文献子类 | Article |
| 英文摘要 | Perivascular adipose tissue (PVAT)-derived adiponectin (APN) is a secreted adipokine that protects against hypertension-related cardiovascular injury. However, the regulation of APN expression in hypertension remains to be explored. In this study, we demonstrated that down-regulation of APN was associated with complement activation in the PVAT of desoxycorticosterone acetate (DOCA)-salt hypertensive mice. Complement 3-deficient hypertensive mice were protected from ANP decrease in the PVAT. APN deficiency blockaded the protective effects of complement inhibition against hypertensive vascular injury. Mechanistically, complement 5a (C5a)-induced TNF-alpha secretion from macrophages is required for inhibiting APN expression in adipocytes. Macrophage depletion reversed C5a agonist peptide-induced TNF-alpha up-regulation and APN down-regulation in the PVAT of DOCA mice. Moreover, we detected increased macrophage infiltration and C5a expression associated with decreased APN expression in adipose tissue from patients with aldosterone-producing adenoma. These results identify a novel interaction between macrophages and adipocytes in the PVAT, where complement-mediated inhibition of APN acts as a potential risk factor for hypertensive vascular inflammation. |
| 学科主题 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| WOS关键词 | ADIPOSE-DERIVED PROTEIN ; MACROPHAGE POLARIZATION ; ANGIOTENSIN-II ; INSULIN SENSITIVITY ; RECEPTOR-BINDING ; 2 PARTS ; TISSUE ; MICE ; PHENOTYPE ; DYSFUNCTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000395671200025 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/921]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Hypertens, Shanghai, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China; 3.Nanjing Med Univ, Ctr Metab Dis Res, Nanjing, Peoples R China, 4.Ruijin Hospital, Dept Cardiol, Luwan Branch, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, State Key Lab Med Gen, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Key Lab Hypertens, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ruan, Cheng-Chao,Ma, Yu,Ge, Qian,et al. Complement-mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension[J]. FASEB JOURNAL,2017,31(3):1120-+. |
| APA | Ruan, Cheng-Chao.,Ma, Yu.,Ge, Qian.,Zhu, Li-Min.,Zhang, Ying.,...&,.(2017).Complement-mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension.FASEB JOURNAL,31(3),1120-+. |
| MLA | Ruan, Cheng-Chao,et al."Complement-mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension".FASEB JOURNAL 31.3(2017):1120-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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