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Circulating microRNA-1a is a biomarker of Graves' disease patients with atrial fibrillation

文献类型：期刊论文

作者Wang, Fang4; Tian, Dong-mei4; Zhang, Sheng-jie2; Yao, Xuan2; Ying, Hao2; Zhang, Ke-qin3; She, Dun-min3; Xue, Ying3; Guo, Fei-fan1; Zhai, Qi-wei1
刊名ENDOCRINE
出版日期2017
卷号57期号:1页码:125-137
关键词Graves' disease Thyroid hormone Atrial fibrillation MicroRNA
ISSN号1355-008X
DOI10.1007/s12020-017-1331-4
文献子类Article
英文摘要It has been increasingly suggested that specific microRNAs expression profiles in the circulation and atrial tissue are associated with the susceptibility to atrial fibrillation. Nonetheless, the role of circulating microRNAs in Graves' disease patients with atrial fibrillation has not yet been well described. The objective of the study was to identify the role of circulating microRNAs as specific biomarkers for the diagnosis of Graves' disease with atrial fibrillation. The expression profiles of eight serum microRNAs, which are found to be critical in the pathogenesis of atrial fibrillation, were determined in patients with Graves' disease with or without atrial fibrillation. MicroRNA expression analysis was performed by real-time PCR in normal control subjects (NC; n = 17), patients with Graves' disease without atrial fibrillation (GD; n = 29), patients with Graves' disease with atrial fibrillation (GD + AF; n = 14), and euthyroid patients with atrial fibrillation (AF; n = 22). Three of the eight serum microRNAs,i.e., miR-1a, miR-26a, and miR-133, had significantly different expression profiles among the four groups. Spearman's correlation analysis showed that the relative expression level of miR-1a was positively correlated with free triiodothyronine (FT3) and free thyroxine (FT4), and negatively related to thyroid stimulating hormone. Spearman's correlations analysis also revealed that the level of miR-1a was negatively correlated with a critical echocardiographic parameter (left atrial diameter), which was dramatically increased in GD + AF group compared to GD group. Furthermore, the receiver-operating characteristic curve analysis indicated that, among the eight microRNAs, miR-1a had the largest area under the receiver-operating characteristic curves not only for discriminating between individuals with and without Graves' disease, but also for predicting the presence of atrial fibrillation in patients with Graves' disease. Our findings showed that the levels of serum miR-1a were significantly decreased in GD + AF group compared with GD group, suggesting that serum miR-1a might serve as a novel biomarker for diagnosis of atrial fibrillation in patients with Graves' disease.
学科主题Endocrinology & Metabolism
WOS关键词CORONARY-ARTERY-DISEASE ; EXPRESSION PROFILES ; CARDIAC CONDUCTION ; CATHETER ABLATION ; THYROID-HORMONE ; HEART ; IDENTIFICATION ; CHANNELS ; SYSTEM ; RISK
语种英语
WOS记录号WOS:000403670300016
出版者SPRINGER
版本出版稿
源URL[http://202.127.25.144/handle/331004/922]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Univ Chinese Acad Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China,
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Univ Chinese Acad Sci, Inst Nutr Sci,Key Lab food safety Res, Shanghai 200031, Peoples R China;
3.Tongji Univ, Tongji Hosp, Dept Endocrinol, Sch Med, Shanghai 200065, Peoples R China;
4.Peoples Hosp Shanghai, Dept Endocrinol, Shanghai 200060, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Fang,Tian, Dong-mei,Zhang, Sheng-jie,et al. Circulating microRNA-1a is a biomarker of Graves' disease patients with atrial fibrillation[J]. ENDOCRINE,2017,57(1):125-137.
APA Wang, Fang.,Tian, Dong-mei.,Zhang, Sheng-jie.,Yao, Xuan.,Ying, Hao.,...&,.(2017).Circulating microRNA-1a is a biomarker of Graves' disease patients with atrial fibrillation.ENDOCRINE,57(1),125-137.
MLA Wang, Fang,et al."Circulating microRNA-1a is a biomarker of Graves' disease patients with atrial fibrillation".ENDOCRINE 57.1(2017):125-137.

入库方式： OAI收割

来源：上海营养与健康研究所

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