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Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases

文献类型：期刊论文

作者Lu, Jianhong7,8,9; Guo, Shuyuan7,8,9; Xue, Xinli7,8,9; Chen, Qun7,8,9; Xia, Lin7,9; Yin, Huiyong6,7,8,9; Chen, Buxing1; Chen, Tingting2; Zhu, Zhengjiang2; Guo, Shuyuan6
刊名REDOX BIOLOGY
出版日期2017
卷号12期号:-页码:899-907
关键词Metabolomics Lipid peroxidation Lipidomics Myocardial infarction Isoprostanes Coronary heart disease (CHD)
ISSN号2213-2317
DOI10.1016/j.redox.2017.04.032
文献子类Article
英文摘要Coronary heart disease (CHD) is a complex human disease associated with inflammation and oxidative stress. The underlying mechanisms and diagnostic biomarkers for the different types of CHD remain poorly defined. Metabolomics has been increasingly recognized as an enabling technique with the potential to identify key metabolomic features in an attempt to understand the pathophysiology and differentiate different stages of CHD. We performed comprehensive metabolomic analysis in human plasma from 28 human subjects with stable angina (SA), myocardial infarction (MI), and healthy control (HC). Subsequent analysis demonstrated a uniquely altered metabolic profile in these CHD: a total of 18, 37 and 36 differential metabolites were identified to distinguish SA from HC, MI from SA, and MI from HC groups respectively. Among these metabolites, glycerophospholipid (GPL) metabolism emerged as the most significantly disturbed pathway. Next, we used a targeted metabolomic approach to systematically analyze GPL, oxidized phospholipid (oxPL), and downstream metabolites derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid and linoleic acid. Surprisingly, lipids associated with lipid peroxidation (LPO) pathways including oxidized PL and isoprostanes, isomers of prostaglandins, were significantly elevated in plasma of MI patients comparing to HC and SA, consistent with the notion that oxidative stress-induced LPO is a prominent feature in CHD. Our studies using the state-of-the-art metabolomics help to understand the underlying biological mechanisms involved in the pathogenesis of CHD; LPO metabolites may serve as potential biomarkers to differentiation MI from SA and HC.
学科主题Biochemistry & Molecular Biology
WOS关键词LOW-DENSITY-LIPOPROTEIN ; STROKE STATISTICS-2016 UPDATE ; OXIDIZED PHOSPHOLIPIDS ; CARDIOVASCULAR-DISEASE ; MASS-SPECTROMETRY ; BIOMARKER DISCOVERY ; OXIDATION-PRODUCTS ; ARTERY-DISEASE ; ARACHIDONIC-ACID ; IN-VITRO
语种英语
WOS记录号WOS:000403328700089
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/925]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Capital Med Univ, Beijing Tiantan Hosp, Dept Cardiol, Beijing 100050, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai 200032, Peoples R China;
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China;
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Syst Biomed,Sch Basic Med Sci, Beijing 100191, Peoples R China;
5.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China,
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai 200031, Peoples R China;
8.Univ Chinese Acad Sci, CAS, Beijing 100049, Peoples R China;
9.Minist Hlth, Key Lab food safety risk Assessment, Beijing 100000, Peoples R China;
推荐引用方式
GB/T 7714		 Lu, Jianhong,Guo, Shuyuan,Xue, Xinli,et al. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases[J]. REDOX BIOLOGY,2017,12(-):899-907.
APA Lu, Jianhong.,Guo, Shuyuan.,Xue, Xinli.,Chen, Qun.,Xia, Lin.,...&,.(2017).Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases.REDOX BIOLOGY,12(-),899-907.
MLA Lu, Jianhong,et al."Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases".REDOX BIOLOGY 12.-(2017):899-907.

入库方式： OAI收割

来源：上海营养与健康研究所

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