Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma
文献类型：期刊论文
| 作者 | Li, Hui1,2,3; Wang, Junbo1,3; Li, Xiang2; Liu, Jie2; Gao, Ying2; Li, Xiang4; Jin, Langping5; Yang, Fan5; Wang, Ouchen5; , |
| 刊名 | INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:5页码:409-419 |
| 关键词 | Lead thyroid adenoma nodular goiter papillary thyroid carcinoma thyroid hormones |
| ISSN号 | 0960-3123 |
| DOI | 10.1080/09603123.2017.1373273 |
| 文献子类 | Article |
| 英文摘要 | Studies have showed that lead was associated with human health. However, the effects of lead on thyroid functions are inconsistent, and studies based on Chinese population are fragmentary. To evaluate the correlation between lead and thyroid functions of Chinese with different thyroid diseases, we conducted a hospital-based study. Ninety-six papillary thyroid carcinoma (PTC), 10 nodular goiter (NG), and 7 thyroid adenoma (TA) patients were recruited from the First Affiliated Hospital of Wenzhou Medical University, China. Serum triiodothyronine (T3), free triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone (TSH) were evaluated with chemiluminescent microparticle immunoassay. Serum lead was assessed with ICP-MASS. Partial correlation was used to explore the correlations of serum lead and thyroid diseases. Compared to PTC, the level of lead was significantly higher in TA, and lower in NG (p < 0.05). This difference remained significant in females when stratified by sex. Serum lead was negatively correlated with TSH (r(s) = -0.27, p < 0.05) in PTC group. T3 was positively related to lead at quartile4 (r(s) = 0.61, p < 0.05) in PTC group. No significant correlations were observed between lead and FT3 or FT4 in any group. The results suggested that lead might have different etiological roles in these three thyroid diseases. |
| 学科主题 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| WOS关键词 | CANCER-MORTALITY ; SMELTER WORKERS ; HEAVY-METALS ; EXPOSURE ; ADULTS ; BLOOD ; MERCURY ; SYSTEM ; HEALTH ; IMPACT |
| 语种 | 英语 |
| WOS记录号 | WOS:000416612600008 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/926]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, CAS Key Lab Nutr & Metab, Shanghai, Peoples R China; 3.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing, Peoples R China; 4.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China; 5.Wenzhou Med Univ, Dept Surg Oncol, Affiliated Hosp 1, Wenzhou, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Li, Hui,Wang, Junbo,Li, Xiang,et al. Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH,2017,27(5):409-419. |
| APA | Li, Hui.,Wang, Junbo.,Li, Xiang.,Liu, Jie.,Gao, Ying.,...&,.(2017).Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma.INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH,27(5),409-419. |
| MLA | Li, Hui,et al."Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma".INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH 27.5(2017):409-419. |
入库方式： OAI收割
来源：上海营养与健康研究所
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