Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection
文献类型：期刊论文
| 作者 | Li, Xiang2,3; Liu, Chu-Xiao2,3; Zhang, Yang2,3; Jiang, Shan2,3; Yin, Qing-Fei2,3; Yao, Run-Wen2,3; Chen, Ling-Ling1,2,3; Xue, Wei4; Wei, Jia4; Yang, Li4 |
| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2017 |
| 卷号 | 67期号:2页码:214-+ |
| 关键词 | mouse bone marrow myeloid cell proliferation cytokine c-KIT Fpr2 Lin(-)c-Kit(+)Sca1(+)cells SCF |
| ISSN号 | 1097-2765 |
| DOI | 10.1016/j.molcel.2017.05.023 |
| 文献子类 | Article |
| 英文摘要 | Circular RNAs (circRNAs) generated via back-splicing are enhanced by flanking complementary sequences. Expression levels of circRNAs vary under different conditions, suggesting participation of protein factors in their biogenesis. Using genome-wide siRNA screening that targets all human unique genes and an efficient circRNA expression reporter, we identify double-stranded RNA-binding domain containing immune factors NF90/NF110 as key regulators in circRNA biogenesis. NF90/NF110 promote circRNA production in the nucleus by associating with intronic RNA pairs juxtaposing the circRNA-forming exon(s); they also interact with mature circRNAs in the cytoplasm. Upon viral infection, circRNA expression is decreased, in part owing to the nuclear export of NF90/NF110 to the cytoplasm. Meanwhile, NF90/NF110 released from circRNP complexes bind to viral mRNAs as part of their functions in antiviral immune response. Our results therefore implicate a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | RNA-PROTEIN INTERACTIONS ; CIRCULAR RNAS ; MESSENGER-RNA ; EXON CIRCULARIZATION ; BINDING PROTEINS ; MAMMALIAN-CELLS ; NONCODING RNAS ; STEM-CELLS ; NF90 ; PHOSPHORYLATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000405908100007 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/927]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China, 2.Univ Chinese Acad Sci, Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Key Lab Mol Androl, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci,Key Lab Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Xiang,Liu, Chu-Xiao,Zhang, Yang,et al. Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection[J]. MOLECULAR CELL,2017,67(2):214-+. |
| APA | Li, Xiang.,Liu, Chu-Xiao.,Zhang, Yang.,Jiang, Shan.,Yin, Qing-Fei.,...&,.(2017).Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection.MOLECULAR CELL,67(2),214-+. |
| MLA | Li, Xiang,et al."Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection".MOLECULAR CELL 67.2(2017):214-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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