Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques
文献类型：期刊论文
| 作者 | He, Zhisong9; Han, Dingding9; Guijarro, Patricia9; Yu, Qianhui9; Oleksiak, Anna9; Jiang, Shasha9; Gruenewald, Stefan9; Han, Dingding1; Efimova, Olga2; Khaitovich, Philipp2,5 |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 20期号:6页码:886-+ |
| 关键词 | Advanced glycation end products (AGEs) Mobility AGEs inhibitors Dietary intervention strategies |
| ISSN号 | 1097-6256 |
| DOI | 10.1038/nn.4548 |
| 文献子类 | Article |
| 英文摘要 | While human cognitive abilities are clearly unique, underlying changes in brain organization and function remain unresolved. Here we characterized the transcriptome of the cortical layers and adjacent white matter in the prefrontal cortexes of humans, chimpanzees and rhesus macaques using unsupervised sectioning followed by RNA sequencing. More than 20% of detected genes were expressed predominantly in one layer, yielding 2,320 human layer markers. While the bulk of the layer markers were conserved among species, 376 switched their expression to another layer in humans. By contrast, only 133 of such changes were detected in the chimpanzee brain, suggesting acceleration of cortical reorganization on the human evolutionary lineage. Immunohistochemistry experiments further showed that human-specific expression changes were not limited to neurons but affected a broad spectrum of cortical cell types. Thus, despite apparent histological conservation, human neocortical organization has undergone substantial changes affecting more than 5% of its transcriptome. |
| 学科主题 | Neurosciences & Neurology |
| WOS关键词 | PREFRONTAL CORTEX ; HUMAN BRAIN ; RNA-SEQ ; CEREBRAL-CORTEX ; SUBPLATE ZONE ; EXPRESSION ; EVOLUTION ; GENE ; ORGANIZATION ; NEURONS |
| 语种 | 英语 |
| WOS记录号 | WOS:000402016900019 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/931]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Jinan Univ, Big Data Decis Inst, Guangzhou, Guangdong, Peoples R China; 2.Skolkovo Inst Sci & Technol, Skolkovo, Russia; 3.Univ Chinese Acad Sci, Beijing, Peoples R China; 4.Kurchatov Inst, Dept Neurosci, Natl Res Ctr, Moscow, Russia; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 6.Immanuel Kant Baltic Fed Univ, Kaliningrad, Russia; 7.Max Planck Inst Evolutionary Anthropol, Leipzig, Germany; 8.Chinese Acad Sci, SIBS, PICB, Comparat Biol Grp, Shanghai, Peoples R China, 9.Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, SIBS, CAS Key Lab Computat Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | He, Zhisong,Han, Dingding,Guijarro, Patricia,et al. Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques[J]. NATURE NEUROSCIENCE,2017,20(6):886-+. |
| APA | He, Zhisong.,Han, Dingding.,Guijarro, Patricia.,Yu, Qianhui.,Oleksiak, Anna.,...&,.(2017).Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques.NATURE NEUROSCIENCE,20(6),886-+. |
| MLA | He, Zhisong,et al."Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques".NATURE NEUROSCIENCE 20.6(2017):886-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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