Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective
文献类型：期刊论文
| 作者 | Chen, Lei2,3; Li, JiaRui2; Wang, ShaoPeng2; Cai, Yu-Dong2; Zhang, Yu-Hang1; Huang, Tao1; Zhang, YunHua4; , |
| 刊名 | GENES
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:12页码:392 |
| 关键词 | obesity disease gene OMIM disease class protein-protein interaction |
| ISSN号 | 2073-4425 |
| DOI | 10.3390/genes8120392 |
| 文献子类 | Review |
| 英文摘要 | The number of obesity cases is rapidly increasing in developed and developing countries, thereby causing significant health problems worldwide. The pathologic factors of obesity at the molecular level are not fully characterized, although the imbalance between energy intake and consumption is widely recognized as the main reason for fat accumulation. Previous studies reported that obesity can be caused by the dysfunction of genes associated with other diseases, such as myocardial infarction, hence providing new insights into dissecting the pathogenesis of obesity by investigating its associations with other diseases. In this study, we investigated the relationship between obesity and diseases from Online Mendelian Inheritance in Man (OMIM) databases on the protein-protein interaction (PPI) network. The obesity genes and genes of one OMIM disease were mapped onto the network, and the interaction scores between the two gene sets were investigated on the basis of the PPI of individual gene pairs, thereby inferring the relationship between obesity and this disease. Results suggested that diseases related to nutrition and endocrine are the top two diseases that are closely associated with obesity. This finding is consistent with our general knowledge and indicates the reliability of our obtained results. Moreover, we inferred that diseases related to psychiatric factors and bone may also be highly related to obesity because the two diseases followed the diseases related to nutrition and endocrine according to our results. Numerous obesity-disease associations were identified in the literature to confirm the relationships between obesity and the aforementioned four diseases. These new results may help understand the underlying molecular mechanisms of obesity-disease co-occurrence and provide useful insights for disease prevention and intervention. |
| 学科主题 | Genetics & Heredity |
| WOS关键词 | FATTY LIVER-DISEASE ; ONLINE MENDELIAN INHERITANCE ; INDUCED INSULIN-RESISTANCE ; SMALL HETERODIMER PARTNER ; SHORTEST-PATH ALGORITHM ; PITUITARY-ADRENAL AXIS ; ANKYLOSING-SPONDYLITIS ; ALZHEIMERS-DISEASE ; METABOLIC SYNDROME ; NUTRITIONAL-STATUS |
| 语种 | 英语 |
| WOS记录号 | WOS:000419212400053 |
| 出版者 | MDPI AG |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/935]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 3.Shanghai Maritime Univ, Coll Informat Engn, Shanghai 201306, Peoples R China; 4.Anhui Agr Univ, Sch Resources & Environm, Anhui Prov Key Lab Farmland Ecol Conversat & Poll, Hefei 230036, Anhui, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Li, JiaRui,Wang, ShaoPeng,et al. Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective[J]. GENES,2017,8(12):392. |
| APA | Chen, Lei.,Li, JiaRui.,Wang, ShaoPeng.,Cai, Yu-Dong.,Zhang, Yu-Hang.,...&,.(2017).Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective.GENES,8(12),392. |
| MLA | Chen, Lei,et al."Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective".GENES 8.12(2017):392. |
入库方式： OAI收割
来源：上海营养与健康研究所
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