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Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway

文献类型：期刊论文

作者Wang, Ye1; Yang, Qi-Wei1; Zhou, Tie1; Shi, Min-Feng1; Cheng, Yan-Qiong1; Sun, Ying-Hao1; Yang, Qi-Wei2; Yang, Qing2; Cui, Xin-Gang2; Shi, Min-Feng3
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
出版日期2017
卷号12期号:-页码:2569-2579
ISSN号1178-2013
关键词cuprous oxide nanoparticle prostate cancer CRPC nanomedicine Wnt signaling pathway
DOI10.2147/IJN.S130537
文献子类Article
英文摘要Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, whether CONPs have the potential to treat castration-resistant prostate cancer is still unknown. Here, using the castration-resistant PC-3 human prostate cancer cell line as a model, we report that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells. CONPs can also attenuate the stemness of cancer cells and inhibit the Wnt signaling pathway, both of which highlight the great potential of CONPs as a new clinical castration-resistant prostate cancer therapy.
学科主题Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS关键词ANDROGEN-DEPRIVATION THERAPY ; HIPPO PATHWAY ; TUMOR-CELLS ; COPPER
语种英语
出版者DOVE MEDICAL PRESS LTD
WOS记录号WOS:000397973500001
版本出版稿
源URL[http://202.127.25.144/handle/331004/939]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Second Mil Med Univ, Changhai Hosp, Dept Urol, 800 Xiangyin Rd, Shanghai, Peoples R China;
2.Second Mil Med Univ, Dept Urol, Affiliated Hosp 3, 800 Xiangyin Rd, Shanghai 200433, Peoples R China;
3.Second Mil Med Univ, Changhai Hosp, Reprod Ctr, Shanghai, Peoples R China;
4.Chinese Acad Sci, Reprod Ctr, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714		 Wang, Ye,Yang, Qi-Wei,Zhou, Tie,et al. Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12(-):2569-2579.
APA Wang, Ye.,Yang, Qi-Wei.,Zhou, Tie.,Shi, Min-Feng.,Cheng, Yan-Qiong.,...&,.(2017).Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway.INTERNATIONAL JOURNAL OF NANOMEDICINE,12(-),2569-2579.
MLA Wang, Ye,et al."Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway".INTERNATIONAL JOURNAL OF NANOMEDICINE 12.-(2017):2569-2579.

入库方式： OAI收割

来源：上海营养与健康研究所

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