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Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?

文献类型：期刊论文

作者Li, Shengxian6; Ma, Jing6; Tao, Tao6; Huang, Rong6; Liao, Yu6; Yue, Jiang6; Zheng, Jun6; Wang, Lihua6; Liu, Wei6; Sun, Yun5
刊名JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
出版日期2017
卷号102期号:3页码:810-821
关键词Diabetes Intermittent fasting Fasting-mimicking diet Beta cells Fatty liver Gut microbiota
ISSN号0021-972X
DOI10.1210/jc.2016-2692
文献子类Article
英文摘要Context: Polycystic ovary syndrome ( PCOS) is a complex syndrome showing clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and hyperandrogenism. Polyunsaturated fatty acids (PUFAs) and their derivatives, both tightly linked to PCOS and obesity, play important roles in inflammation and reproduction. Objective: This study aimed to investigate serum lipid profiles in newly diagnosed patients with PCOS using lipidomics and correlate these features with the hyperinsulinemia and hyperandrogenism associated with PCOS and obesity. Design and Setting: Thirty-two newly diagnosed women with PCOS and 34 controls were divided into obese and lean subgroups. A PCOS rat model was used to validate results of the human studies. Main Outcome Measures: Serum lipid profiles, including phospholipids, free fatty acids (FFAs), and bioactive lipids, were analyzed using gas chromatography-mass spectrometry (MS) and liquid chromatography-MS. Results: Elevation in phosphatidylcholine and a concomitant decrease in lysophospholipid were found in obese patients with PCOS vs lean controls. Obese patients with PCOS had decreased PUFA levels and increased levels of long-chain saturated fatty acids vs lean controls. Serum bioactive lipids downstream of arachidonic acid were increased in obese controls, but reduced in both obese and lean patients with PCOS vs their respective controls. Conclusions: Patients with PCOS showed abnormal levels of phosphatidylcholine, FFAs, and PUFA metabolites. Circulating insulin and androgens may have opposing effects on lipid profiles in patients with PCOS, particularly on the bioactive lipid metabolites derived from PUFAs. These clinical observations warrant further studies of the molecular mechanisms and clinical implications of PCOS and obesity.
学科主题Endocrinology & Metabolism
WOS关键词POLYCYSTIC-OVARY-SYNDROME ; IONIZATION-MASS-SPECTROMETRY ; IMPAIRED GLUCOSE-TOLERANCE ; FAT-CELL LIPOLYSIS ; NONALCOHOLIC STEATOHEPATITIS ; BIOLOGICAL SAMPLES ; OLDER CHINESE ; RISK-FACTORS ; OBESE WOMEN ; TESTOSTERONE
语种英语
WOS记录号WOS:000398118100008
出版者ENDOCRINE SOC
版本出版稿
源URL[http://202.127.25.144/handle/331004/944]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China,
2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab food safety Res, Shanghai 200031, Peoples R China; Chinese Acad Sci, Shanghai Inst Biol Sci, Mass Spectrometry Res Ctr, Inst Nutr Sci, Shanghai 200031, Peoples R China; Minist Hlth, Key Lab food safety risk Assessment, Beijing 100021, Peoples R China;
4.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Biobank, Shanghai 200127, Peoples R China;
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Assisted Reprod & Reprod Genet, Ctr Reprod Med,Renji Hosp, Shanghai 200127, Peoples R China;
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Endocrinol, 160 Pujian Rd, Shanghai 200127, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Shengxian,Ma, Jing,Tao, Tao,et al. Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2017,102(3):810-821.
APA Li, Shengxian.,Ma, Jing.,Tao, Tao.,Huang, Rong.,Liao, Yu.,...&,.(2017).Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,102(3),810-821.
MLA Li, Shengxian,et al."Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 102.3(2017):810-821.

入库方式： OAI收割

来源：上海营养与健康研究所

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