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Differentiated demographic histories and local adaptations between Sherpas and Tibetans

文献类型：期刊论文

作者Zhang, Chao7,8; Lu, Yan8; Feng, Qidi7,8; Wang, Xiaoji7,8; Lou, Haiyi8; Liu, Jiaojiao6,7,8; Ning, Zhilin7,8; Yuan, Kai7,8; Wang, Yuchen7,8; Zhou, Ying7,8
刊名GENOME BIOLOGY
出版日期2017
卷号18期号:-页码:115
ISSN号1474-760X
关键词Sherpa Tibetan Next-generation sequencing High-altitude adaptation Population history Gene flow
DOI10.1186/s13059-017-1242-y
文献子类Article
英文摘要Background: The genetic relationships reported by recent studies between Sherpas and Tibetans are controversial. To gain insights into the population history and the genetic basis of high-altitude adaptation of the two groups, we analyzed genome-wide data in 111 Sherpas (Tibet and Nepal) and 177 Tibetans (Tibet and Qinghai), together with available data from present-day human populations. Results: Sherpas and Tibetans show considerable genetic differences and can be distinguished as two distinct groups, even though the divergence between them (similar to 3200-11,300 years ago) is much later than that between Han Chinese and either of the two groups (similar to 6200-16,000 years ago). Sub-population structures exist in both Sherpas and Tibetans, corresponding to geographical or linguistic groups. Differentiation of genetic variants between Sherpas and Tibetans associated with adaptation to either high-altitude or ultraviolet radiation were identified and validated by genotyping additional Sherpa and Tibetan samples. Conclusions: Our analyses indicate that both Sherpas and Tibetans are admixed populations, but the findings do not support the previous hypothesis that Tibetans derive their ancestry from Sherpas and Han Chinese. Compared to Tibetans, Sherpas show higher levels of South Asian ancestry, while Tibetans show higher levels of East Asian and Central Asian/Siberian ancestry. We propose a new model to elucidate the differentiated demographic histories and local adaptations of Sherpas and Tibetans.
学科主题Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS关键词HIGH-ALTITUDE ADAPTATION ; GENETIC-EVIDENCE ; HAPLOTYPE STRUCTURE ; POSITIVE SELECTION ; GENOME SEQUENCES ; NORTHERN CHINA ; NITRIC-OXIDE ; HYPOXIA ; HIMALAYAS ; ORIGINS
语种英语
出版者BIOMED CENTRAL LTD
WOS记录号WOS:000403323600002
版本出版稿
源URL[http://202.127.25.144/handle/331004/946]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Minist Educ MOE, Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China;
2.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China,
3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China;
4.Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China;
5.Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China;
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
8.Chinese Acad Sci, Max Planck Independent Res Grp Populat Genom, CAS MPG Partner Inst Computat Biol PICB, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Chao,Lu, Yan,Feng, Qidi,et al. Differentiated demographic histories and local adaptations between Sherpas and Tibetans[J]. GENOME BIOLOGY,2017,18(-):115.
APA Zhang, Chao.,Lu, Yan.,Feng, Qidi.,Wang, Xiaoji.,Lou, Haiyi.,...&,.(2017).Differentiated demographic histories and local adaptations between Sherpas and Tibetans.GENOME BIOLOGY,18(-),115.
MLA Zhang, Chao,et al."Differentiated demographic histories and local adaptations between Sherpas and Tibetans".GENOME BIOLOGY 18.-(2017):115.

入库方式： OAI收割

来源：上海营养与健康研究所

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