Network-Based Method for Identifying Co-Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues
文献类型：期刊论文
| 作者 | Chen, Lei1,3; Cai, Yu-Dong1; Pan, Hongying4,5; Zhang, Yu-Hang6; Kong, XiangYin6; Huang, Tao6; Feng, Kaiyan2; , |
| 刊名 | GENES
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:10页码:252 |
| 关键词 | co-regeneration bone dentin nerve vessel protein-protein interaction |
| ISSN号 | 2073-4425 |
| DOI | 10.3390/genes8100252 |
| 文献子类 | Article |
| 英文摘要 | Bone and dental diseases are serious public health problems. Most current clinical treatments for these diseases can produce side effects. Regeneration is a promising therapy for bone and dental diseases, yielding natural tissue recovery with few side effects. Because soft tissues inside the bone and dentin are densely populated with nerves and vessels, the study of bone and dentin regeneration should also consider the co-regeneration of nerves and vessels. In this study, a network-based method to identify co-regeneration genes for bone, dentin, nerve and vessel was constructed based on an extensive network of protein-protein interactions. Three procedures were applied in the network-based method. The first procedure, searching, sought the shortest paths connecting regeneration genes of one tissue type with regeneration genes of other tissues, thereby extracting possible co-regeneration genes. The second procedure, testing, employed a permutation test to evaluate whether possible genes were false discoveries; these genes were excluded by the testing procedure. The last procedure, screening, employed two rules, the betweenness ratio rule and interaction score rule, to select the most essential genes. A total of seventeen genes were inferred by the method, which were deemed to contribute to co-regeneration of at least two tissues. All these seventeen genes were extensively discussed to validate the utility of the method. |
| 学科主题 | Genetics & Heredity |
| WOS关键词 | PROTEIN INTERACTION NETWORK ; GROWTH-HORMONE RECEPTOR ; SHORTEST-PATH ALGORITHM ; CARCINOMA-RELATED GENES ; CELL-CYCLE PROGRESSION ; NEURAL STEM-CELLS ; SONIC-HEDGEHOG ; SIGNALING PATHWAYS ; BLOOD-VESSEL ; IN-VITRO |
| 语种 | 英语 |
| WOS记录号 | WOS:000414862300017 |
| 出版者 | MDPI AG |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/947]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; 2.Guangdong AIB Polytech, Dept Comp Sci, Guangzhou 510507, Guangdong, Peoples R China, 3.Shanghai Maritime Univ, Coll Informat Engn, Shanghai 201306, Peoples R China; 4.Harvard Univ, Harvard Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA; 5.Harvard Univ, Brigham & Womens Hosp, Dept Orthoped Surg, Boston, MA 02115 USA; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Cai, Yu-Dong,Pan, Hongying,et al. Network-Based Method for Identifying Co-Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues[J]. GENES,2017,8(10):252. |
| APA | Chen, Lei.,Cai, Yu-Dong.,Pan, Hongying.,Zhang, Yu-Hang.,Kong, XiangYin.,...&,.(2017).Network-Based Method for Identifying Co-Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues.GENES,8(10),252. |
| MLA | Chen, Lei,et al."Network-Based Method for Identifying Co-Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues".GENES 8.10(2017):252. |
入库方式： OAI收割
来源：上海营养与健康研究所
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