miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2
文献类型：期刊论文
| 作者 | Zhang, Xudong3; Zhao, Jingyu3; Xu, Jiajia3; Geng, Yiyun3; Dai, Liming3; Huang, Yan3; Dai, Kerong3; Zhang, Xiaoling1,3; Wang, Chuandong1; Fu, Sai-Chuen2 |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:-页码:e2734 |
| 关键词 | chemotherapy ovarian cancer premenopausal women propensity score matching |
| ISSN号 | 2041-4889 |
| DOI | 10.1038/cddis.2017.146 |
| 文献子类 | Article |
| 英文摘要 | Osteoarthritis (OA), characterized by insufficient extracellular matrix synthesis and cartilage degeneration, is known as an incurable disease because its pathogenesis is poorly elucidated. Thus far, limited information is available regarding the pathophysiological role of microRNAs (miRNAs) in OA. In this study, we investigated the specific function of miR-146a in OA pathophysiology using mouse OA models. We found that the articular cartilage degeneration of miR-146a knockout (KO) mice was alleviated compared with that of the wild-type (WT) mice in spontaneous and instability-induced OA models. We demonstrate that miR-146a aggravated pro-inflammatory cytokines induced suppressing the expression of cartilage matrix-associated genes. We further identified calcium/calmodulin-dependent protein kinase II delta (Camk2d) and protein phosphatase 3, regulatory subunit B, beta isoform (Ppp3r2, also known as calcineurin B, type II) were essential targets of miR-146a in regulating cartilage homeostasis. Moreover, we found that surgical-induced OA mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2. These results suggested that miR-146a has a crucial role in maintaining cartilage homeostasis. MiR-146a inhibition in chondrocytes can be a potential therapeutic strategy to ameliorate OA. |
| 学科主题 | Cell Biology |
| WOS关键词 | ARTICULAR CHONDROCYTES ; MOUSE MODELS ; EXPRESSION ; DIFFERENTIATION ; MICE ; MICRORNA-146A ; CALCINEURIN ; ARTHRITIS ; NFATC1 ; INDUCTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000401093800021 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/948]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Dept Orthoped Surg, Xin Hua Hosp, Sch Med, Shanghai, Peoples R China; 2.Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Fac Med, Hong Kong, Hong Kong, Peoples R China, 3.Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xudong,Zhao, Jingyu,Xu, Jiajia,et al. miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2[J]. CELL DEATH & DISEASE,2017,8(-):e2734. |
| APA | Zhang, Xudong.,Zhao, Jingyu.,Xu, Jiajia.,Geng, Yiyun.,Dai, Liming.,...&,.(2017).miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.CELL DEATH & DISEASE,8(-),e2734. |
| MLA | Zhang, Xudong,et al."miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2".CELL DEATH & DISEASE 8.-(2017):e2734. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。