Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations
文献类型：期刊论文
| 作者 | Hu, Yao10; Zhu, Jingwen10; Li, Huaixing10; Lin, Xu10; Tanaka, Toshiko9; Ferrucci, Luigi9; Guan, Weihua8; Manichaikul, Ani7,19; Steffen, Lyn M.7; Liang, Shuang6 |
| 刊名 | JOURNAL OF LIPID RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 58期号:5页码:974-981 |
| ISSN号 | 0022-2275 |
| 关键词 | genetics fatty acid/desaturases fatty acid/metabolism fatty acid/biosynthesis monounsaturated fatty acid |
| DOI | 10.1194/jlr.P071860 |
| 文献子类 | Article |
| 英文摘要 | MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic syndrome (MS). Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry. We identified novel genome-wide significant associations for vaccenic acid at FADS1/2 and PKD2L1 [log(10)(Bayes factor). >= 8.07] and for gondoic acid at FADS1/2 and GCKR [log(10)(Bayes factor) >= 6.22], and also observed improved fine-mapping resolutions at FADS1/2 and GCKR loci. The greatest improvement was observed at GCKR, where the number of variants in the 99% credible set was reduced from 16 (covering 94.8 kb) to 5 (covering 19.6 kb, including a missense variant rs1260326) after trans-ethnic meta-analysis. We also confirmed the previously reported associations of PKD2L1, FADS1/2, GCKR, and HIF1AN with palmitoleic acid and of FADS1/2 and LPCAT3 with oleic acid in the Chinese-specific GWAS and the trans-ethnic meta-analyses. Pathway-based analyses suggested that the identified loci were in unsaturated FA metabolism and signaling pathways.(jl) Our findings provide novel insight into the genetic basis relevant to MUFA metabolism and biology. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; MONOUNSATURATED FATTY-ACIDS ; NOVO LIPOGENESIS PATHWAY ; CORONARY-HEART-DISEASE ; C-REACTIVE PROTEIN ; METABOLIC SYNDROME ; OLDER CHINESE ; PALMITOLEIC ACID ; ADIPOSE-TISSUE ; RISK |
| 语种 | 英语 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| WOS记录号 | WOS:000400479800017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/950]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA; 2.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA; 3.Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA; 4.Univ Washington, Sch Publ Hlth, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA; 5.Univ Sydney, Sydney Med Sch, George Inst Global Hlth, Sydney, NSW, Australia; 6.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA; 7.Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA; 8.Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA; 9.NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA; 10.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, Yao,Zhu, Jingwen,Li, Huaixing,et al. Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations[J]. JOURNAL OF LIPID RESEARCH,2017,58(5):974-981. |
| APA | Hu, Yao.,Zhu, Jingwen.,Li, Huaixing.,Lin, Xu.,Tanaka, Toshiko.,...&,.(2017).Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations.JOURNAL OF LIPID RESEARCH,58(5),974-981. |
| MLA | Hu, Yao,et al."Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations".JOURNAL OF LIPID RESEARCH 58.5(2017):974-981. |
入库方式： OAI收割
来源：上海营养与健康研究所
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