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Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis

文献类型：期刊论文

作者Li, Shufen1,2; Jin, Wen1,2,5; Ma, Xuefei1,2; Wang, Kankan1,2; Chen, Li5; Dong, Fangyi5; Zhu, Hongming5; Li, Junmin5; Ma, Yunlin3,4; ,
刊名SCIENTIFIC REPORTS
出版日期2017
卷号7期号:-页码:17998
关键词glioma gene expression Monte Carlo feature selection Johnson reducer algorithm support vector machine
ISSN号2045-2322
DOI10.1038/s41598-017-18278-x
文献子类Article
英文摘要Previous studies have demonstrated an association between high body mass index (BMI) and acute myeloid leukemias (AML), particularly acute promyelocytic leukemia (APL). However, the effect of obesity and overweight on the incidence of AML is not supported by all studies, and the relationship between obesity and prognosis of AML and APL has not been established. Thus, we conducted a meta-analysis to determine the role of BMI on the risk and clinical outcome of AML, including APL. Twenty-six eligible studies enrolling 12,971 AML (including 866 APL) patients were retrieved and analyzed. Overweight and obesity was associated with an increased incidence of AML (relative risk [RR], 1.23; 95% confidence interval [CI], 1.12-1.35; P < 0.001). High BMI did not significantly affect overall survival (OS) (hazard ratio [HR], 0.97; 95% CI, 0.92-1.03; P = 0.323) or disease-free survival (HR, 0.98; 95% CI, 0.88-1.10; P = 0.755) in patients with non-APL AML. By contrast, APL patients with high BMI had shorter OS (HR, 1.77; 95% CI, 1.26-2.48; P = 0.001) and a higher risk of differentiation syndrome (HR, 1.53; 95% CI, 1.03-2.27, P = 0.04). Overall, our findings suggest that patients with overweight or obesity have a higher incidence of AML, and high BMI is a predictor of adverse clinical outcomes in APL.
学科主题Science & Technology - Other Topics
WOS关键词DIFFERENTIATION SYNDROME ; HEMATOLOGICAL MALIGNANCY ; METABOLIC SYNDROME ; PREDICTIVE FACTORS ; POOLED ANALYSIS ; AML PATIENTS ; CANCER-RISK ; OBESITY ; CHEMOTHERAPY ; IMPACT
语种英语
WOS记录号WOS:000418562100038
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/951]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China;
2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, State Key Lab Med Genom, Shanghai 200025, Peoples R China;
3.Univ Chinese Acad Sci, Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China,
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, State Key Lab Med Genom, Shanghai, Peoples R China;
5.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Hematol, Shanghai 200025, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Shufen,Jin, Wen,Ma, Xuefei,et al. Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis[J]. SCIENTIFIC REPORTS,2017,7(-):17998.
APA Li, Shufen.,Jin, Wen.,Ma, Xuefei.,Wang, Kankan.,Chen, Li.,...&,.(2017).Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis.SCIENTIFIC REPORTS,7(-),17998.
MLA Li, Shufen,et al."Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis".SCIENTIFIC REPORTS 7.-(2017):17998.

入库方式： OAI收割

来源：上海营养与健康研究所

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