The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
文献类型：期刊论文
| 作者 | Zhou, Wu5; Xu, Jun5; Cao, Ming-Guo5; Fang, Zheng-Yu5; Ye, Xiao-lei4; Guan, Guang-Hui4; Liu, Qiong4; Li, Ling-Yun1; Qian, Yue-Hui3; Xie, Dong2 |
| 刊名 | SCIENCE SIGNALING
 |
| 出版日期 | 2017 |
| 卷号 | 10期号:483页码:- |
| 关键词 | tissue-specific expressed genes transcriptome tissue classification support vector machine feature selection |
| ISSN号 | 1945-0877 |
| DOI | 10.1126/scisignal.aak9557 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. The pathophysiological course of metastasis is mediated by the dynamic plasticity of cancer cells, which enables them to shift between epithelial and mesenchymal phenotypes through a transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET). Using a mouse model of spontaneous metastatic breast cancer, we investigated the molecular mediators of metastatic competence within a heterogeneous primary tumor and how these cells then manipulated their epithelial-mesenchymal plasticity during the metastatic process. We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b. We found that this ability enabled H19 to modulate the expression of the microRNA targets Git2 and Cyth3, respectively, which encode regulators of the RAS superfamily member adenosine 5'-diphosphate (ADP) ribosylation factor (ARF), a guanosine triphosphatase (GTPase) that promotes cell migration associated with EMT and disseminating tumor cells. Decreasing the abundance of H19 or manipulating that of members in its axis prevented metastasis from grafts in syngeneic mice. Abundance of H19, GIT2, and CYTH3 in patient samples further suggests that H19 might be exploited as a biomarker for metastatic cells within breast tumors and perhaps as a therapeutic target to prevent metastasis. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; GTPASE-ACTIVATING PROTEINS ; RIBOSYLATION FACTOR 6 ; TUMOR-METASTASIS ; EXPRESSION ; FAMILY ; ZEB1 ; SIGNATURE ; GROWTH ; DISSEMINATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000403148100002 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/952]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Peoples Hosp Lishui City, Lab Med, Lishui 323000, Peoples R China; 2.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China, 3.Tianjin Med Univ, Dept Lab Anim Sci, Tianjin 300007, Peoples R China; 4.Ningbo Inst Med Sci, Div Drugs & Pharmacol, Ningbo 315020, Zhejiang, Peoples R China; 5.Lishui Univ, Coll Med & Hlth, Dept Med, Lishui 323000, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Wu,Xu, Jun,Cao, Ming-Guo,et al. The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b[J]. SCIENCE SIGNALING,2017,10(483):-. |
| APA | Zhou, Wu.,Xu, Jun.,Cao, Ming-Guo.,Fang, Zheng-Yu.,Ye, Xiao-lei.,...&,.(2017).The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.SCIENCE SIGNALING,10(483),-. |
| MLA | Zhou, Wu,et al."The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b".SCIENCE SIGNALING 10.483(2017):-. |
入库方式： OAI收割
来源：上海营养与健康研究所
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