Proteogenomic characterization and integrative analysis of glioblastoma multiforme
文献类型：期刊论文
| 作者 | Song, Ying-Chun5; Lu, Gai-Xia5; Xue, Shao-Bo5; Kong, Rui5; Li, Dan5; Chai, Li5; Cai, Ming-Xiang5; Sun, Ming5; Mao, Wei-Qing5; Fan, Su-Yun5 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:57页码:97304-97312 |
| 关键词 | GBM glioma proteomics analysis gene expression analysis Bioinformatics Analysis |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.21937 |
| 文献子类 | Article |
| 英文摘要 | Glioblastoma multiforme (GBM), the most aggressive and lethal primary brain tumor, is characterized by very low life expectancy. Understanding the genomic and proteogenomic characteristics of GBM is essential for devising better therapeutic approaches. Here, we performed proteomic profiling of 8 GBM and paired normal brain tissues. In parallel, comprehensive integrative genomic analysis of GBM was performed in silico using mRNA microarray and sequencing data. Two whole transcript expression profiling cohorts were used - a set of 3 normal brain tissues and 22 glioma tissue samples and a cohort of 5 normal brain tissues and 49 glioma tissue samples. A validation cohort included 529 GBM patients from The Cancer Genome Atlas datasets. We identified 36 molecules commonly changed at the level of the gene and protein, including up-regulated TGFBI and NES and down-regulated SNCA and HSPA12A. Single amino acid variant analysis identified 200 proteins with high mutation rates in GBM samples. We further identified 14 differentially expressed genes with high-level protein modification, among which NES and TNC showed differential expression at the protein level. Moreover, higher expression of NES and TNC mRNAs correlated with shorter overall survival, suggesting that these genes constitute potential biomarkers for GBM. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | CELLS ; TUMOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000419395000076 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/955]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 10, Dept Pathol, Sch Med, Shanghai 200072, Peoples R China; 2.Jilin Univ, China Japan Unoin Hosp, Dept Biobank, Changchun 130033, Jilin, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Dept Orthoped Surg, Shanghai 200032, Peoples R China; 4.East China Normal Univ, Coll Chem & Mol Engn, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Shanghai 200062, Peoples R China, 5.Tongji Univ, Shanghai Peoples Hosp 10, Dept Nucl Med, Sch Med, Shanghai 200072, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China; 7.Ganzhou City Peoples Hosp, Jiangxi Prov Tumor Hosp, Dept Radiol, Nanchang 330029, Jiangxi, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Song, Ying-Chun,Lu, Gai-Xia,Xue, Shao-Bo,et al. Proteogenomic characterization and integrative analysis of glioblastoma multiforme[J]. ONCOTARGET,2017,8(57):97304-97312. |
| APA | Song, Ying-Chun.,Lu, Gai-Xia.,Xue, Shao-Bo.,Kong, Rui.,Li, Dan.,...&,.(2017).Proteogenomic characterization and integrative analysis of glioblastoma multiforme.ONCOTARGET,8(57),97304-97312. |
| MLA | Song, Ying-Chun,et al."Proteogenomic characterization and integrative analysis of glioblastoma multiforme".ONCOTARGET 8.57(2017):97304-97312. |
入库方式： OAI收割
来源：上海营养与健康研究所
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