Induced dopaminergic neurons: A new promise for Parkinson's disease
文献类型：期刊论文
| 作者 | Xu, Zhimin1,2,3,4; Jiang, Houbo1,2; Feng, Jian1,2; Schilling, Haley2; Chu, Xingkun3,4; Chen, Shengdi3,4; , |
| 刊名 | REDOX BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:-页码:606-612 |
| 关键词 | Parkinson's disease Induced dopaminergic neuron Induced neuron Induced pluripotent stem cell Transcription factor |
| ISSN号 | 2213-2317 |
| DOI | 10.1016/j.redox.2017.01.009 |
| 文献子类 | Review |
| 英文摘要 | Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on midbrain DA neurons derived from human fetal mesencephalic tissue, human embryonic stem cells (hESC) or human induced pluripotent stem cells (iPSC). Recent development in the direct conversion of human fibroblasts to induced dopaminergic (iDA) neurons offers new opportunities for transplantation study and disease modeling in PD. The iDA neurons are generated directly from human fibroblasts in a short period of time, bypassing lengthy differentiation process from human pluripotent stem cells and the concern for potentially tumorigenic mitotic cells. They exhibit functional dopaminergic neurotransmission and relieve locomotor symptoms in animal models of Parkinson's disease. In this review, we will discuss this recent development and its implications to Parkinson's disease research and therapy. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | DIRECT LINEAGE CONVERSION ; EFFICIENT DIRECT CONVERSION ; NEURAL PROGENITOR CELLS ; HUMAN FIBROBLASTS ; FUNCTIONAL-NEURONS ; STEM-CELLS ; TRANSCRIPTION FACTORS ; SEROTONERGIC NEURONS ; DEFINED CONDITIONS ; CEREBRAL-CORTEX |
| 语种 | 英语 |
| WOS记录号 | WOS:000398212000059 |
| 出版者 | ELSEVIER SCIENCE BV |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/956]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Vet Affairs Western New York Healthcare Syst, Buffalo, NY 14215 USA; 2.SUNY Buffalo, Dept Physiol & Biophys, 124 Sherman Hall, Buffalo, NY 14214 USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Neurodegenerat Dis, Shanghai 200025, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xu, Zhimin,Jiang, Houbo,Feng, Jian,et al. Induced dopaminergic neurons: A new promise for Parkinson's disease[J]. REDOX BIOLOGY,2017,11(-):606-612. |
| APA | Xu, Zhimin.,Jiang, Houbo.,Feng, Jian.,Schilling, Haley.,Chu, Xingkun.,...&,.(2017).Induced dopaminergic neurons: A new promise for Parkinson's disease.REDOX BIOLOGY,11(-),606-612. |
| MLA | Xu, Zhimin,et al."Induced dopaminergic neurons: A new promise for Parkinson's disease".REDOX BIOLOGY 11.-(2017):606-612. |
入库方式： OAI收割
来源：上海营养与健康研究所
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