Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma
文献类型：期刊论文
| 作者 | Liu, Gang1,2; Dong, Chuanpeng1,2; Wang, Xing1,2; Zheng, Yu1,2; Xu, Huilin1,2; Liu, Lei1,2; Hou, Guojun3; Zhan, Xiaohui4; , |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:58页码:98360-98370 |
| 关键词 | colorectal cancer prognosis transcription factor model |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.21312 |
| 文献子类 | Article |
| 英文摘要 | Clinical and pathological indicators are inadequate for prognosis of stage II and III colorectal carcinoma (CRC). In this study, we utilized the activity of regulatory factors, univariate Cox regression and random forest for variable selection and developed a multivariate Cox model to predict the overall survival of Stage II/III colorectal carcinoma in GSE39582 datasets (469 samples). Patients in low-risk group showed a significant longer overall survival and recurrence-free survival time than those in high-risk group. This finding was further validated in five other independent datasets (GSE14333, GSE17536, GSE17537, GSE33113, and GSE37892). Besides, associations between clinicopathological information and risk score were analyzed. A nomogram including risk score was plotted to facilitate the utilization of risk score. The risk score model is also demonstrated to be effective on predicting both overall and recurrence free survival of chemotherapy received patients. After performing Gene Set Enrichment Analysis (GSEA) between high and low risk groups, we found that several cell-cell interaction KEGG pathways were identified. Funnel plot results showed that there was no publication bias in these datasets. In summary, by utilizing the regulatory activity in stage II and III colorectal carcinoma, the risk score successfully predicts the survival of 1021 stage II/III CRC patients in six independent datasets. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | POOR-PROGNOSIS ; CANCER STATISTICS ; TUMOR PROGRESSION ; LIVER METASTASES ; COMPETING-RISKS ; EXPRESSION ; OVEREXPRESSION ; GFI1 ; BIOMARKER ; ANDROGEN |
| 语种 | 英语 |
| WOS记录号 | WOS:000419392300052 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/959]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China; 2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China; 3.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Liu, Gang,Dong, Chuanpeng,Wang, Xing,et al. Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma[J]. ONCOTARGET,2017,8(58):98360-98370. |
| APA | Liu, Gang.,Dong, Chuanpeng.,Wang, Xing.,Zheng, Yu.,Xu, Huilin.,...&,.(2017).Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma.ONCOTARGET,8(58),98360-98370. |
| MLA | Liu, Gang,et al."Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma".ONCOTARGET 8.58(2017):98360-98370. |
入库方式： OAI收割
来源：上海营养与健康研究所
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