中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma

文献类型:期刊论文

作者Liu, Gang1,2; Dong, Chuanpeng1,2; Wang, Xing1,2; Zheng, Yu1,2; Xu, Huilin1,2; Liu, Lei1,2; Hou, Guojun3; Zhan, Xiaohui4; ,
刊名ONCOTARGET
出版日期2017
卷号8期号:58页码:98360-98370
关键词colorectal cancer prognosis transcription factor model
ISSN号1949-2553
DOI10.18632/oncotarget.21312
文献子类Article
英文摘要Clinical and pathological indicators are inadequate for prognosis of stage II and III colorectal carcinoma (CRC). In this study, we utilized the activity of regulatory factors, univariate Cox regression and random forest for variable selection and developed a multivariate Cox model to predict the overall survival of Stage II/III colorectal carcinoma in GSE39582 datasets (469 samples). Patients in low-risk group showed a significant longer overall survival and recurrence-free survival time than those in high-risk group. This finding was further validated in five other independent datasets (GSE14333, GSE17536, GSE17537, GSE33113, and GSE37892). Besides, associations between clinicopathological information and risk score were analyzed. A nomogram including risk score was plotted to facilitate the utilization of risk score. The risk score model is also demonstrated to be effective on predicting both overall and recurrence free survival of chemotherapy received patients. After performing Gene Set Enrichment Analysis (GSEA) between high and low risk groups, we found that several cell-cell interaction KEGG pathways were identified. Funnel plot results showed that there was no publication bias in these datasets. In summary, by utilizing the regulatory activity in stage II and III colorectal carcinoma, the risk score successfully predicts the survival of 1021 stage II/III CRC patients in six independent datasets.
学科主题Oncology ; Cell Biology
WOS关键词POOR-PROGNOSIS ; CANCER STATISTICS ; TUMOR PROGRESSION ; LIVER METASTASES ; COMPETING-RISKS ; EXPRESSION ; OVEREXPRESSION ; GFI1 ; BIOMARKER ; ANDROGEN
语种英语
WOS记录号WOS:000419392300052
出版者IMPACT JOURNALS LLC
版本出版稿
源URL[http://202.127.25.144/handle/331004/959]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China;
2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China;
3.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, Shanghai, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China,
推荐引用方式
GB/T 7714
Liu, Gang,Dong, Chuanpeng,Wang, Xing,et al. Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma[J]. ONCOTARGET,2017,8(58):98360-98370.
APA Liu, Gang.,Dong, Chuanpeng.,Wang, Xing.,Zheng, Yu.,Xu, Huilin.,...&,.(2017).Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma.ONCOTARGET,8(58),98360-98370.
MLA Liu, Gang,et al."Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma".ONCOTARGET 8.58(2017):98360-98370.

入库方式: OAI收割

来源:上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。