Unique sequence organization and small RNA expression of a "selfish" B chromosome
文献类型：期刊论文
| 作者 | Li, Yue2,3; Chen, Jian2,3; Jing, Xueyuan A.5,6,7; Aldrich, John C.5,6,7; Clifford, C.5,6,7; Ferree, Patrick M.5,6,7; Akbari, Omar S.1,4; , |
| 刊名 | CHROMOSOMA
 |
| 出版日期 | 2017 |
| 卷号 | 126期号:6页码:753-768 |
| 关键词 | B chromosomes Small RNAs Noncoding DNA repeats Satellite DNA Nasonia vitripennis Testis Spermatogenesis |
| ISSN号 | 0009-5915 |
| DOI | 10.1007/s00412-017-0641-x |
| 文献子类 | Article |
| 英文摘要 | B chromosomes are found in numerous plants and animals. These nonessential, supernumerary chromosomes are often composed primarily of noncoding DNA repeats similar to those found within transcriptionally "silenced" heterochromatin. In order to persist within their resident genomes, many B chromosomes exhibit exceptional cellular behaviors, including asymmetric segregation into gametes and induction of genome elimination during early development. An important goal in understanding these behaviors is to identify unique B chromosome sequences and characterize their transcriptional contributions. We investigated these properties by examining a paternally transmitted B chromosome known as paternal sex ratio (PSR), which is present in natural populations of the jewel wasp Nasonia vitripennis. To facilitate its own transmission, PSR severely biases the sex ratio by disrupting early chromatin remodeling processes. Through cytological mapping and other approaches, we identified multiple DNA repeats unique to PSR, as well as those found on the A chromosomes, suggesting that PSR arose through a merger of sequences from both within and outside the N. vitripennis genome. The majority of PSR-specific repeats are interspersed among each other across PSR's long arm, in contrast with the distinct "blocks" observed in other organisms' heterochromatin. Through transcriptional profiling, we identified a subset of repeat-associated, small RNAs expressed by PSR, most of which map to a single PSR-specific repeat. These RNAs are expressed at much higher levels than those arising from A chromosome-linked repeats, suggesting that in addition to its sequence organization, PSR's transcriptional properties differ substantially from the pericentromeric regions of the normal chromosomes. |
| 学科主题 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS关键词 | PATERNAL-SEX-RATIO ; WASP NASONIA-VITRIPENNIS ; DROSOPHILA-MELANOGASTER ; DNA-SEQUENCES ; GENETIC ELEMENTS ; ORIGIN ; PSR ; EVOLUTION ; GENOME ; HETEROCHROMATIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000415626700007 |
| 出版者 | SPRINGER |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/961]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif Riverside, Dept Entomol, Inst Integrat Genome Biol, Riverside, CA 92521 USA; 2.Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 4.Univ Calif Riverside, Riverside Ctr Dis Vector Res, Inst Integrat Genome Biol, Riverside, CA 92521 USA, 5.Claremont Mckenna Coll, WM Keck Sci Dept, 925 N Mills Ave, Claremont, CA 91711 USA; 6.Pitzer Coll, WM Keck Sci Dept, 925 N Mills Ave, Claremont, CA 91711 USA; 7.Scripps Coll, WM Keck Sci Dept, 925 N Mills Ave, Claremont, CA 91711 USA; |
| 推荐引用方式 GB/T 7714 | Li, Yue,Chen, Jian,Jing, Xueyuan A.,et al. Unique sequence organization and small RNA expression of a "selfish" B chromosome[J]. CHROMOSOMA,2017,126(6):753-768. |
| APA | Li, Yue.,Chen, Jian.,Jing, Xueyuan A..,Aldrich, John C..,Clifford, C..,...&,.(2017).Unique sequence organization and small RNA expression of a "selfish" B chromosome.CHROMOSOMA,126(6),753-768. |
| MLA | Li, Yue,et al."Unique sequence organization and small RNA expression of a "selfish" B chromosome".CHROMOSOMA 126.6(2017):753-768. |
入库方式： OAI收割
来源：上海营养与健康研究所
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