Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition
文献类型：期刊论文
| 作者 | Tang, J.1,3; Chen, G-Q1,2,3; Zhan, M-N2; Yin, Q-Q2; Zhou, C-X2; Wang, C-L2; Wo, L-L2; He, M.2; Zhao, Q.2; , |
| 刊名 | ONCOGENESIS
 |
| 出版日期 | 2017 |
| 卷号 | 6期号:-页码:e387 |
| ISSN号 | 2157-9024 |
| 关键词 | dioxin endothelial cell apoptosis EP3 p38 MAPK Bcl-2 |
| DOI | 10.1038/oncsis.2017.85 |
| 文献子类 | Article |
| 英文摘要 | Aberrant activation of nuclear factor-kappa B (NF-kappa B) has been observed in a wide range of human cancers and is thought to promote tumorigenesis and metastasis. As a central component of NF-kappa B pathway, p65 protein level is tightly regulated and could be subjected to proteasome degradation. Here we demonstrated that p65 can bind to HSC70 with four consensus recognition motif in its RHD domain and be constitutively transported to the lysosome membrane to bind with lysosome-associated membrane protein type 2A and degraded within the lysosome in two epithelial cell lines, proposing that p65 can be degraded by chaperone-mediated autophagy (CMA). Of great importance, there is a decreased CMA activity together with impaired degradation of p65 in a process of epithelial-mesenchymal transition (EMT). The resulted accumulation of p65 leads to higher NF-kappa B activity and contributes to the progression and maintenance of the EMT program. Taken together, our results define a novel regulatory mechanism for the important transcription factor p65, and these findings would shed new light on the inhibition of EMT, as well as metastasis of cancer cells. |
| 学科主题 | Oncology |
| WOS关键词 | NF-KAPPA-B ; LYSOSOMAL DEGRADATION ; TUMOR-METASTASIS ; CANCER CELLS ; DISEASE ; TARGETS ; PHOSPHORYLATION ; PROMOTES ; LEADS |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000415011700003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/962]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Natl Minist Educ, Dept Pathophysiol,Sch Med, 280 Chong Qing South Rd, Shanghai 200025, Peoples R China, 3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tang, J.,Chen, G-Q,Zhan, M-N,et al. Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition[J]. ONCOGENESIS,2017,6(-):e387. |
| APA | Tang, J..,Chen, G-Q.,Zhan, M-N.,Yin, Q-Q.,Zhou, C-X.,...&,.(2017).Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition.ONCOGENESIS,6(-),e387. |
| MLA | Tang, J.,et al."Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition".ONCOGENESIS 6.-(2017):e387. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。